The stimulus-induced release of 5-hydroxytryptamine and tryptophan from superfused rat brain synaptosomes

Collard, K. J., Evans, T. N. W., Suter, H. A. and Wilkinson, Lawrence Stephen ORCID: https://orcid.org/0000-0002-9337-6124 1982. The stimulus-induced release of 5-hydroxytryptamine and tryptophan from superfused rat brain synaptosomes. Journal of Neural Transmission 53 (2-3) , pp. 223-230. 10.1007/BF01243414

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Abstract

The synthesis of 5-hydroxytryptamine (5-HT) from3H-tryptophan in rat forebrain synaptosomes was studied. Synaptosomes which had been preincubated with3H-tryptophan were perfused with Krebs solution and the release of tryptophan, 5-HT and 5-hydroxyindoleacetic acid (5-HIAA) was determined. K+ depolarization induced a Ca2+-dependent release of 5-HT and tryptophan but had no effect on 5-HIAA efflux. This finding suggests that the release of tryptophan is unlikely to be a non-specific effect of depolarization.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Medicine Neuroscience and Mental Health Research Institute (NMHRI) Psychology
Subjects:	R Medicine > R Medicine (General)
Publisher:	Springer Verlag
ISSN:	0300-9564
Last Modified:	31 Oct 2022 10:36
URI:	https://orca.cardiff.ac.uk/id/eprint/85465

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