Nonviral gene delivery: techniques and implications for molecular medicine

Parker, Alan L. ORCID: https://orcid.org/0000-0002-9302-1761, Newman, Christopher, Briggs, Simon, Seymour, Leonard and Sheridan, Paul J. 2004. Nonviral gene delivery: techniques and implications for molecular medicine. Expert Reviews in Molecular Medicine 5 , pp. 1-15. 10.1017/S1462399403006562

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Abstract

Medical research continues to illuminate the origins of many human diseases. Gene therapy has been widely proposed as a novel strategy by which this knowledge can be used to deliver new and improved therapies. Viral gene transfer is relatively efficient but there are concerns relating to the use of viral vectors in humans. Conversely, nonviral vectors appear safe but inefficient. Therefore, the development of an efficient nonviral vector remains a highly desirable goal. This review focuses on the numerous challenges preventing efficient nonviral gene transfer in vivo and discusses the many technologies that have been adopted to overcome these problems

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > R Medicine (General)
Uncontrolled Keywords:	Nonviral gene delivery; gene therapy; ultrasound; naked DNA; polyplex; lipoplex; transgen
Publisher:	Cambridge University Press
ISSN:	1462-3994
Last Modified:	31 Oct 2022 10:52
URI:	https://orca.cardiff.ac.uk/id/eprint/86513

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