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Submicrometer axial resolution optical coherence tomography

Považay, Boris, Hermann, Boris, Unterhuber, Angelika, Bizheva, K, Sattmann, Harald, Fercher, Adolf F., Drexler, Wolfgang, Apolonski, A., Wadsworth, W. J., Knight, J. C., Russell, P. St. J., Vetterlein, M and Scherzer, E 2002. Submicrometer axial resolution optical coherence tomography. Optics Letters 27 (20) , pp. 1800-1802. 10.1364/OL.27.001800

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Optical coherence tomography (OCT) with unprecedented submicrometer axial resolution achieved by use of a photonic crystal fiber in combination with a compact sub-10-fs Ti:sapphire laser (Femtolasers Produktions) is demonstrated for what the authors believe is the first time. The emission spectrum ranges from 550 to 950 nm (?c=725 nm , Pout=27 mW) , resulting in a free-space axial OCT resolution of ~0.75 ?m , corresponding to ~0.5 ?m in biological tissue. Submicrometer-resolution OCT is demonstrated in vitro on human colorectal adenocarcinoma cells HT-29. This novel light source has great potential for development of spectroscopic OCT because its spectrum covers the absorption bands of several biological chromophores.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Optometry and Vision Sciences
ISSN: 15394794
Last Modified: 04 Jun 2017 01:36

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