Submicrometer axial resolution optical coherence tomography

Považay, Boris, Hermann, Boris ORCID: https://orcid.org/0000-0001-8658-485X, Unterhuber, Angelika ORCID: https://orcid.org/0000-0002-1251-3001, Bizheva, K, Sattmann, Harald, Fercher, Adolf F., Drexler, Wolfgang, Apolonski, A., Wadsworth, W. J., Knight, J. C., Russell, P. St. J., Vetterlein, M and Scherzer, E 2002. Submicrometer axial resolution optical coherence tomography. Optics Letters 27 (20) , pp. 1800-1802. 10.1364/OL.27.001800

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Abstract

Optical coherence tomography (OCT) with unprecedented submicrometer axial resolution achieved by use of a photonic crystal fiber in combination with a compact sub-10-fs Ti:sapphire laser (Femtolasers Produktions) is demonstrated for what the authors believe is the first time. The emission spectrum ranges from 550 to 950 nm (?c=725 nm , Pout=27 mW) , resulting in a free-space axial OCT resolution of ~0.75 ?m , corresponding to ~0.5 ?m in biological tissue. Submicrometer-resolution OCT is demonstrated in vitro on human colorectal adenocarcinoma cells HT-29. This novel light source has great potential for development of spectroscopic OCT because its spectrum covers the absorption bands of several biological chromophores.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Optometry and Vision Sciences
ISSN:	15394794
Last Modified:	17 Oct 2022 08:43
URI:	https://orca.cardiff.ac.uk/id/eprint/870

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