Scaling-down antibody radiolabeling reactions with zirconium-89

Knight, James C., Paisey, Stephen James ORCID: https://orcid.org/0000-0002-2274-3708, Dabkowski, Adam M., Marculescu, Cristina, Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X, Marshall, Christopher and Cornelissen, Bart 2016. Scaling-down antibody radiolabeling reactions with zirconium-89. Dalton Transactions 45 (15) , pp. 6343-6347. 10.1039/C5DT04774A

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Abstract

The most widely cited procedures for radiolabeling antibodies with zirconium-89 for immuno-PET require multi-milligram amounts of antibody which can be cost-prohibitive, particularly during the research and development process. We therefore sought to develop a reliable 89Zr-radiolabeling procedure that provides high radiochemical yields at the microgram scale.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Medicine
Subjects:	R Medicine > R Medicine (General)
Publisher:	Royal Society of Chemistry
ISSN:	1477-9226
Date of Acceptance:	7 March 2016
Last Modified:	31 Oct 2025 22:25
URI:	https://orca.cardiff.ac.uk/id/eprint/88047

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