Diurnal stability of gamma-aminobutyric acid concentration in visual and sensorimotor cortex

Evans, Christopher John ORCID: https://orcid.org/0000-0002-6619-4245, McGonigle, David ORCID: https://orcid.org/0000-0001-9595-6352 and Edden, Richard Anthony Edward 2010. Diurnal stability of gamma-aminobutyric acid concentration in visual and sensorimotor cortex. Journal of Magnetic Resonance Imaging 31 (1) , pp. 204-209. 10.1002/jmri.21996

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Abstract

Purpose:To establish the diurnal stability of edited magnetic resonance spectroscopy measurements of gamma-aminobutyric acid (GABA) in visual and sensorimotor regions of the brain. Materials and Methods:GABA measurements were made in two regions of the brain (an occipital, “visual” region and a “sensorimotor” region centered on the precentral gyrus) using the MEGA-PRESS editing method, scanning eight healthy adults at five timepoints during a single day. GABA concentration was quantified from the ratio of the GABA integral to the unsuppressed water signal. Results:No significant effect of time on GABA concentration was seen (P = 0.35). GABA was shown to be significantly more concentrated in visual regions than in sensorimotor regions (1.10 i.u. and 1.03 i.u., respectively; P = 0.050). Coefficients of variability (CVs) across all subjects of 9.1% and 12% (visual and sensorimotor) were significantly higher than mean within-subjects CVs of 6.5% and 8.8. Conclusion:This study demonstrates the excellent reproducibility of MEGA-PRESS detection of GABA, demonstrating that the method is sufficiently sensitive to detect inter-subject variability, and suggests that (within the sensitivity limits of current measurements) time of day can be ignored in the design of MRS studies of visual and sensorimotor regions.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences Chemistry Cardiff University Brain Research Imaging Centre (CUBRIC) Psychology
Subjects:	R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Publisher:	John Wiley & Sons
ISSN:	1053-1807
Last Modified:	17 Oct 2022 10:38
URI:	https://orca.cardiff.ac.uk/id/eprint/8822

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