Evans, Christopher John  ORCID: https://orcid.org/0000-0002-6619-4245, McGonigle, David ORCID: https://orcid.org/0000-0001-9595-6352 and Edden, Richard Anthony Edward
2010.
Diurnal stability of gamma-aminobutyric acid concentration in visual and sensorimotor cortex.
Journal of Magnetic Resonance Imaging
31
(1)
, pp. 204-209.
10.1002/jmri.21996
|
Abstract
Purpose:To establish the diurnal stability of edited magnetic resonance spectroscopy measurements of gamma-aminobutyric acid (GABA) in visual and sensorimotor regions of the brain. Materials and Methods:GABA measurements were made in two regions of the brain (an occipital, “visual” region and a “sensorimotor” region centered on the precentral gyrus) using the MEGA-PRESS editing method, scanning eight healthy adults at five timepoints during a single day. GABA concentration was quantified from the ratio of the GABA integral to the unsuppressed water signal. Results:No significant effect of time on GABA concentration was seen (P = 0.35). GABA was shown to be significantly more concentrated in visual regions than in sensorimotor regions (1.10 i.u. and 1.03 i.u., respectively; P = 0.050). Coefficients of variability (CVs) across all subjects of 9.1% and 12% (visual and sensorimotor) were significantly higher than mean within-subjects CVs of 6.5% and 8.8. Conclusion:This study demonstrates the excellent reproducibility of MEGA-PRESS detection of GABA, demonstrating that the method is sufficiently sensitive to detect inter-subject variability, and suggests that (within the sensitivity limits of current measurements) time of day can be ignored in the design of MRS studies of visual and sensorimotor regions.
| Item Type: | Article |
|---|---|
| Date Type: | Publication |
| Status: | Published |
| Schools: | Schools > Biosciences Schools > Chemistry Research Institutes & Centres > Cardiff University Brain Research Imaging Centre (CUBRIC) Schools > Psychology |
| Subjects: | R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry |
| Publisher: | John Wiley & Sons |
| ISSN: | 1053-1807 |
| Last Modified: | 17 Oct 2022 10:38 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/8822 |
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