Epithelial Pten is dispensable for intestinal homeostasis but suppresses adenoma development and progression after Apc mutation

Marsh Durban, Victoria ORCID: https://orcid.org/0000-0003-1645-1618, Winton, Douglas J., Williams, Geraint Trefor ORCID: https://orcid.org/0000-0003-3768-9940, Dubois, Nicole, Trumpp, Andreas, Sansom, Owen J. ORCID: https://orcid.org/0000-0001-9540-3010 and Clarke, Alan Richard ORCID: https://orcid.org/0000-0002-4281-426X 2008. Epithelial Pten is dispensable for intestinal homeostasis but suppresses adenoma development and progression after Apc mutation. Nature Genetics 40 (12) , pp. 1436-1444. 10.1038/ng.256

Full text not available from this repository.

Abstract

PTEN acts as a tumor suppressor in a range of tissue types and has been implicated in the regulation of intestinal stem cells. To study Pten function in the intestine, we used various conditional transgenic strategies to specifically delete Pten from the mouse intestinal epithelium. We show that Pten loss specifically within the adult or embryonic epithelial cell population does not affect the normal architecture or homeostasis of the epithelium. However, loss of Pten in the context of Apc deficiency accelerates tumorigenesis through increased activation of Akt, leading to rapid development of adenocarcinoma. We conclude that Pten is redundant in otherwise normal intestinal epithelium and epithelial stem cells but, in the context of activated Wnt signaling, suppresses progression to adenocarcinoma through modulation of activated Akt levels.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences European Cancer Stem Cell Research Institute (ECSCRI) Medicine
Subjects:	Q Science > QH Natural history > QH426 Genetics
Publisher:	Nature Publishing Group
ISSN:	1061-4036
Last Modified:	02 Dec 2022 11:50
URI:	https://orca.cardiff.ac.uk/id/eprint/8852

Citation Data

Cited 86 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item