A role for the placenta in programming maternal mood and childhood behavioural disorders

Janssen, Anna B., Kertes, Darlene A., McNamara, Grainne, Braithwaite, Elizabeth C., Creeth, Hugo, Glover, Vivette I. and John, Rosalind Margaret ORCID: https://orcid.org/0000-0002-3827-7617 2016. A role for the placenta in programming maternal mood and childhood behavioural disorders. Journal of Neuroendocrinology 28 (8) 10.1111/jne.12373

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Abstract

Substantial data demonstrate that the early‐life environment, including in utero, plays a key role in later life disease. In particular, maternal stress during pregnancy has been linked to adverse behavioural and emotional outcomes in children. Data from human cohort studies and experimental animal models suggest that modulation of the developing epigenome in the foetus by maternal stress may contribute to the foetal programming of disease. Here, we summarise insights gained from recent studies that may advance our understanding of the role of the placenta in mediating the association between maternal mood disorders and offspring outcomes. First, the placenta provides a record of exposures during pregnancy, as indicated by changes in the placental trancriptome and epigenome. Second, prenatal maternal mood may alter placental function to adversely impact foetal and child development. Finally, we discuss the less well established but interesting possibility that altered placental function, more specifically changes in placental hormones, may adversely affect maternal mood and later maternal behaviour, which can also have consequence for offspring well‐being.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences
Additional Information:	PDF uploaded in accordance with publisher's policies at http://www.sherpa.ac.uk/romeo/issn/0953-8194/ (accessed 21.4.16).
Publisher:	Wiley-Blackwell
ISSN:	0953-8194
Funders:	MRC
Date of First Compliant Deposit:	18 April 2016
Date of Acceptance:	28 January 2016
Last Modified:	06 May 2023 18:48
URI:	https://orca.cardiff.ac.uk/id/eprint/89365

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