Maness, Nicholas J., Valentine, Laura E., May, Gemma E., Reed, Jason, Piaskowski, Shari M., Soma, Taeko, Furlott, Jessica, Rakasz, Eva G., Friedrich, Thomas C., Price, David  ORCID: https://orcid.org/0000-0001-9416-2737, Gostick, Emma, Hughes, Austin L., Sidney, John, Sette, Alessandro, Wilson, Nancy A. and Watkins, David I.
2007.
AIDS virus-specific CD8+T lymphocytes against an immunodominant cryptic epitope select for viral escape.
Journal of Experimental Medicine
204
(11)
, pp. 2505-2512.
10.1084/jem.20071261
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Abstract
Cryptic major histocompatibility complex class I epitopes have been detected in several pathogens, but their importance in the immune response to AIDS viruses remains unknown. Here, we show that Mamu-B*17+ simian immunodeficiency virus (SIV)mac239-infected rhesus macaques that spontaneously controlled viral replication consistently made strong CD8+ T lymphocyte (CD8-TL) responses against a cryptic epitope, RHLAFKCLW (cRW9). Importantly, cRW9-specific CD8-TL selected for viral variation in vivo and effectively suppressed SIV replication in vitro, suggesting that they might play a key role in the SIV-specific response. The discovery of an immunodominant CD8-TL response in elite controller macaques against a cryptic epitope suggests that the AIDS virus–specific cellular immune response is likely far more complex than is generally assumed.
| Item Type: | Article |
|---|---|
| Status: | Published |
| Schools: | Schools > Medicine |
| Subjects: | Q Science > QR Microbiology > QR180 Immunology Q Science > QR Microbiology > QR355 Virology |
| Additional Information: | Publisher's PDF uploaded in accordance with policy at http://www.sherpa.ac.uk/romeo/issn/0022-1007/ [accessed 22/06/2016] |
| Publisher: | Rockefeller University Press |
| ISSN: | 0022-1007 |
| Date of First Compliant Deposit: | 25 April 2016 |
| Date of Acceptance: | 25 September 2007 |
| Last Modified: | 05 May 2023 13:37 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/89922 |
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