Almeida, Jorge R., Price, David  ORCID: https://orcid.org/0000-0001-9416-2737, Papagno, Laura, Arkoub, Zaïna Aït, Sauce, Delphine, Bornstein, Ethan, Asher, Tedi E., Samri, Assia, Schnuriger, Aurélie, Theodorou, Ioannis, Costagliola, Dominique, Rouzioux, Christine, Agut, Henri, Marcelin, Anne-Geneviève, Douek, Daniel, Autran, Brigitte and Appay, Victor
2007.
Superior control of HIV-1 replication by CD8+T cells is reflected by their avidity, polyfunctionality, and clonal turnover.
Journal of Experimental Medicine
204
(10)
, pp. 2473-2485.
10.1084/jem.20070784
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Abstract
The key attributes of CD8+ T cell protective immunity in human immunodeficiency virus (HIV) infection remain unclear. We report that CD8+ T cell responses specific for Gag and, in particular, the immunodominant p24 epitope KK10 correlate with control of HIV-1 replication in human histocompatibility leukocyte antigen (HLA)–B27 patients. To understand further the nature of CD8+ T cell–mediated antiviral efficacy, we performed a comprehensive study of CD8+ T cells specific for the HLA-B27–restricted epitope KK10 in chronic HIV-1 infection based on the use of multiparametric flow cytometry together with molecular clonotypic analysis and viral sequencing. We show that B27-KK10–specific CD8+ T cells are characterized by polyfunctional capabilities, increased clonal turnover, and superior functional avidity. Such attributes are interlinked and constitute the basis for effective control of HIV-1 replication. These data on the features of effective CD8+ T cells in HIV infection may aid in the development of successful T cell vaccines.
| Item Type: | Article |
|---|---|
| Status: | Published |
| Schools: | Schools > Medicine |
| Additional Information: | Published PDF uploaded in accordance with policy at http://www.sherpa.ac.uk/romeo/issn/0022-1007/ [accessed 22/06/2016] |
| Publisher: | Rockefeller University Press |
| ISSN: | 0022-1007 |
| Date of First Compliant Deposit: | 27 April 2016 |
| Date of Acceptance: | 31 August 2007 |
| Last Modified: | 06 May 2023 15:14 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/90109 |
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