Superior control of HIV-1 replication by CD8+T cells is reflected by their avidity, polyfunctionality, and clonal turnover

Almeida, Jorge R., Price, David ORCID: https://orcid.org/0000-0001-9416-2737, Papagno, Laura, Arkoub, Zaïna Aït, Sauce, Delphine, Bornstein, Ethan, Asher, Tedi E., Samri, Assia, Schnuriger, Aurélie, Theodorou, Ioannis, Costagliola, Dominique, Rouzioux, Christine, Agut, Henri, Marcelin, Anne-Geneviève, Douek, Daniel, Autran, Brigitte and Appay, Victor 2007. Superior control of HIV-1 replication by CD8+T cells is reflected by their avidity, polyfunctionality, and clonal turnover. Journal of Experimental Medicine 204 (10) , pp. 2473-2485. 10.1084/jem.20070784

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Abstract

The key attributes of CD8+ T cell protective immunity in human immunodeficiency virus (HIV) infection remain unclear. We report that CD8+ T cell responses specific for Gag and, in particular, the immunodominant p24 epitope KK10 correlate with control of HIV-1 replication in human histocompatibility leukocyte antigen (HLA)–B27 patients. To understand further the nature of CD8+ T cell–mediated antiviral efficacy, we performed a comprehensive study of CD8+ T cells specific for the HLA-B27–restricted epitope KK10 in chronic HIV-1 infection based on the use of multiparametric flow cytometry together with molecular clonotypic analysis and viral sequencing. We show that B27-KK10–specific CD8+ T cells are characterized by polyfunctional capabilities, increased clonal turnover, and superior functional avidity. Such attributes are interlinked and constitute the basis for effective control of HIV-1 replication. These data on the features of effective CD8+ T cells in HIV infection may aid in the development of successful T cell vaccines.

Item Type:	Article
Status:	Published
Schools:	Medicine
Additional Information:	Published PDF uploaded in accordance with policy at http://www.sherpa.ac.uk/romeo/issn/0022-1007/ [accessed 22/06/2016]
Publisher:	Rockefeller University Press
ISSN:	0022-1007
Date of First Compliant Deposit:	27 April 2016
Date of Acceptance:	31 August 2007
Last Modified:	06 May 2023 15:14
URI:	https://orca.cardiff.ac.uk/id/eprint/90109

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