Understanding the complexity and malleability of T-cell recognition

Miles, John James, McCluskey, James, Rossjohn, Jamie ORCID: https://orcid.org/0000-0002-2020-7522 and Gras, Stephanie 2015. Understanding the complexity and malleability of T-cell recognition. Immunology and Cell Biology 93 (5) , pp. 433-441. 10.1038/icb.2014.112

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Abstract

T cells are the master regulators of immune system function, continually walking the biological tightrope between adequate host defence and accidental host pathology. Tolerance is maintained or broken through an intricate structural interplay between the T-cell receptor (TCR) and major histocompatibility complex (MHC) molecule cradling peptide antigens (p). Recent advances in structural biology have shown that the TCR/pMHC interface is surprising precise and extraordinarily malleable. We have seen that seemingly minor changes in the TCR/pMHC interface can abrogate function, as well as substantial conformational changes before and after TCR docking. Our understanding of T-cell biology has also been altered with the knowledge that MHC molecules can bind not only peptides, but also an array of natural and synthetic compounds. Here, we review some examples of the precision and flexibility intrinsic to the TCR/p/MHCI axis.

Item Type:	Article
Date Type:	Published Online
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > R Medicine (General)
Publisher:	Nature Publishing Group
ISSN:	0818-9641
Last Modified:	01 Nov 2022 10:14
URI:	https://orca.cardiff.ac.uk/id/eprint/90783

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