The impact of acute kidney injury in diabetes mellitus

Johnson, Faye, Phillips, Dafydd, Talabani, Bnar, Wonnacott, Alexa ORCID: https://orcid.org/0000-0002-0968-4248, Meran, Soma ORCID: https://orcid.org/0000-0003-3408-3978 and Phillips, Aled ORCID: https://orcid.org/0000-0001-9744-7113 2016. The impact of acute kidney injury in diabetes mellitus. Journal of Thrombosis and Haemostatis 21 (6) , pp. 506-511. 10.1111/nep.12649

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Abstract

Little data exist on outcome of Acute Kidney Injury (AKI) in Diabetes. We describe short-term recovery of renal function, patient mortality and progressive renal dysfunction following AKI in diabetics. METHODS: Using the diagnosis of either diabetes or no diabetes as the defining variable, AKI episodes were identified from records of a clinical biochemsitry department serving a population of 560,000. Patient co-morbidity and mortality were collated from electronic patient records. Outcomes were compared to a non-diabetic cohort with AKI. RESULTS: AKI was identified in 101 diabetic and 392 non-diabetic patients. Patients with Diabetes had less severe AKI, compared to the non-diabetic cohort (AKI stage 1 76% vs 55%, p = 0.0006). Overall acute mortality, and mortality adjusted for co-morbidity, was comparable in the diabetic and non-diabetic groups. Recovery to baseline renal function was greater in diabetic patients (87% vs 63% p = 0.001), and the proportion of patients developing progressive CKD was lower in the (14%) compared to the non-diabetic cohort (48%, p < 0.00001). CONCLUSIONS: Although acute mortality is comparable following an AKI episode in diabetics compared to that associated with AKI in a non-diabetic cohort, for those surviving the acute episode its impact on renal function is significantly less than in a non-diabetic group.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > RZ Other systems of medicine
Publisher:	Wiley-Blackwell
ISSN:	1538-7933
Date of Acceptance:	7 October 2015
Last Modified:	01 Nov 2022 10:16
URI:	https://orca.cardiff.ac.uk/id/eprint/90879

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