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P2X7 receptor-mediated TG2 externalization: a link to inflammatory arthritis?

Aeschlimann, Daniel and Knauper, Vera 2017. P2X7 receptor-mediated TG2 externalization: a link to inflammatory arthritis? Amino Acids 49 (3) , pp. 453-460. 10.1007/s00726-016-2319-8

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Transglutaminases have important roles in stabilizing extracellular protein assemblies in tissue repair processes but some reaction products can stimulate immune activation, leading to chronic inflammatory conditions or autoimmunity. Exacerbated disease in models of inflammatory arthritis has been ascribed to sustained extracellular enzyme activity alongside formation of select protein modifications. Here, we review the evidence, with a focus on the link between P2X7R signaling and TG2 export, a pathway that we have recently discovered which ties extracellular protein modifications into the danger signal-mediated innate immune response. These recent insights offer new opportunities for therapeutic intervention.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Dentistry
Subjects: R Medicine > R Medicine (General)
Uncontrolled Keywords: Transglutaminase P2X7 receptor Purinergic signaling Arthritis Cartilage Inflammation Autoimmunity
Publisher: Springer Verlag
ISSN: 0939-4451
Funders: Arthritis Research UK
Date of First Compliant Deposit: 18 August 2016
Date of Acceptance: 17 August 2016
Last Modified: 12 Apr 2019 14:41

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