Browse by Current Cardiff authors

Moses, Rachael L., Woods, Emma L., Dally, Jordanna, Johns, Jenny, Knauper, Vera ORCID: https://orcid.org/0000-0002-3965-9924, Boyle, Glen M., Gordon, Victoria, Reddell, Paul, Steadman, Robert ORCID: https://orcid.org/0000-0002-1303-2496 and Moseley, Ryan ORCID: https://orcid.org/0000-0002-2812-6735 2024. Epoxytiglianes induce keratinocyte wound healing responses via classical protein kinase C activation to promote skin re-epithelialization. Biochemical Pharmacology 230 (Part 2) , 116607. 10.1016/j.bcp.2024.116607

Antwi, Frank D., Awad, Tufaha, Larin, Meghan, Heesom, Kate, Lewis, Phil, Reddell, Paul, Poghosyan, Zaruhi ORCID: https://orcid.org/0000-0003-4966-7618, Dewitt, Sharon ORCID: https://orcid.org/0000-0001-8169-8241, Moseley, Ryan ORCID: https://orcid.org/0000-0002-2812-6735 and Knäuper, Vera ORCID: https://orcid.org/0000-0002-3965-9924 2024. Tigilanol tiglate-induced changes in secretome profiles alter c-Met phosphorylation and cell surface protein expression in H357 head and neck cancer cells. Cells 13 (11) , 982. 10.3390/cells13110982

Owens, Helen A., Thorburn, Lauren M., Walsby, Elisabeth ORCID: https://orcid.org/0000-0001-8523-5017, Moon, Owen R., Rizkallah, Pierre ORCID: https://orcid.org/0000-0002-9290-0369, Sherwani, Subuhi, Tinsley, Caroline L., Rogers, Louise, Cerutti, Camilla, Ridley, Anne J., Williams, Julie ORCID: https://orcid.org/0000-0002-4069-0259, Knäuper, Vera ORCID: https://orcid.org/0000-0002-3965-9924 and Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908 2024. Alzheimer’s disease-associated P460L variant of EphA1 dysregulates receptor activity and blood brain barrier function. Alzheimer's & Dementia: The Journal of the Alzheimer's Association 20 (3) , pp. 2016-2033. 10.1002/alz.13603

Bauer, Lea, Edwards, Jessica, Heil, Andreas ORCID: https://orcid.org/0000-0002-9536-5402, Dewitt, Sharon ORCID: https://orcid.org/0000-0001-8169-8241, Biebermann, Heike, Aeschlimann, Daniel ORCID: https://orcid.org/0000-0003-0930-7706 and Knauper, Vera ORCID: https://orcid.org/0000-0002-3965-9924 2024. Mesenchymal transglutaminase 2 activates epithelial ADAM17: link to G-protein coupled receptor 56 (ADGRG1) signalling. International Journal of Molecular Sciences 25 (4) , 2329. 10.3390/ijms25042329

Ganesh, Raksha A., Sonpatki, Pranali, Naik, Divya, John, Arivusudar Everad, Sathe, Gajanan, Lakshmikantha, Akhila, Chandrachari, Komal Prasad, Bauer, Lea, Knauper, Vera ORCID: https://orcid.org/0000-0002-3965-9924, Aeschlimann, Daniel ORCID: https://orcid.org/0000-0003-0930-7706, Venkatraaman, Krishnan, Shah, Nameeta and Sirdeshmukh, Ravi 2022. Multi-omics analysis of glioblastoma and glioblastoma cell line: Molecular insights into the functional role of GPR56 in mesenchymal transition. Frontiers in Oncology 12 , 841890. 10.3389/fonc.2022.841890

Howes, Joanna-Marie, Knauper, Vera ORCID: https://orcid.org/0000-0002-3965-9924, Malcor, Jean-Daniel and Farndale, Richard W 2020. Cleavage by MMP-13 renders VWF unable to bind to collagen but increases its platelet-reactivity. Journal of Thrombosis and Haemostatis 18 (4) , pp. 942-954. 10.1111/jth.14729

Mohammed, Rebar N., Wehenkel, Sophie C., Galkina, Elena V., Yates, Emma-Kate, Preece, Graham, Newman, Andrew, Watson, H. Angharad, Ohme, Julia, Bridgeman, John S., Durairaj, Ruban R. P., Moon, Owen R., Ladell, Kristin ORCID: https://orcid.org/0000-0002-9856-2938, Miners, Kelly L., Dolton, Garry, Troeberg, Linda, Kashiwagi, Masahide, Murphy, Gillian, Nagase, Hideaki, Price, David A. ORCID: https://orcid.org/0000-0001-9416-2737, Matthews, R. James, Knauper, Vera ORCID: https://orcid.org/0000-0002-3965-9924 and Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908 2019. ADAM17-dependent proteolysis of L-selectin promotes early clonal expansion of cytotoxic T cells. Scientific Reports 9 , 5487. 10.1038/s41598-019-41811-z

Mattern, Jens, Roghi, Christian S., Hurtz, Melanie, Knauper, Vera ORCID: https://orcid.org/0000-0002-3965-9924, Edwards, Dylan R. and Poghosyan, Zaruhi ORCID: https://orcid.org/0000-0003-4966-7618 2019. ADAM15 mediates upregulation of Claudin-1 expression in breast cancer cells. Scientific Reports 9 (1) , 12540. 10.1038/s41598-019-49021-3

Howes, Joanna-Marie, Pugh, Nicholas, Hamaia, Samir W, Jung, Stephanie M., Knauper, Vera ORCID: https://orcid.org/0000-0002-3965-9924, Malcor, Jean-Daniel and Farndale, Richard W 2018. MMP-13 binds to platelet receptors αIIbβ3 and GPVI and impairs aggregation and thrombus formation. Research and Practice in Thrombosis and Haemostasis 2 (2) , pp. 370-379. 10.1002/rth2.12088

Gaweł-Bęben, K., Ali, N., Ellis, V., Velasco, G., Poghosyan, Z., Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908 and Knauper, Vera ORCID: https://orcid.org/0000-0002-3965-9924 2018. TMEFF2 shedding is regulated by oxidative stress and mediated by ADAMs and transmembrane serine proteases implicated in prostate cancer. Cell Biology International 42 (3) , pp. 273-280. 10.1002/cbin.10832

Aeschlimann, Daniel ORCID: https://orcid.org/0000-0003-0930-7706 and Knauper, Vera ORCID: https://orcid.org/0000-0002-3965-9924 2017. P2X7 receptor-mediated TG2 externalization: a link to inflammatory arthritis? Amino Acids 49 (3) , pp. 453-460. 10.1007/s00726-016-2319-8

Chang, Gin-Wen, Hsiao, Cheng-Chih, Peng, Yen-Ming, Braga, Felipe A. Vieira, Kragten, Natasja A.M., Remmerswaal, Ester B. M., van de Garde, Martijn D. B., Straussberg, Rachel, König, Gabriele M., Kostenis, Evi, Knauper, Vera ORCID: https://orcid.org/0000-0002-3965-9924, Meyaard, Linde, van Lier, René A.W., van Gisbergen, Klaas P.J.M., Lin, Hsi-Hsien and Hamann, Jörg 2016. The adhesion G protein-coupled receptor GPR56/ADGRG1 is an inhibitory receptor on human NK cells. Cell Reports 15 (8) , pp. 1757-1770. 10.1016/j.celrep.2016.04.053

Adamczyk, Magdalena ORCID: https://orcid.org/0000-0002-7405-5157, Griffiths, Rhiannon, Dewitt, Sharon ORCID: https://orcid.org/0000-0001-8169-8241, Knauper, Vera ORCID: https://orcid.org/0000-0002-3965-9924 and Aeschlimann, Daniel ORCID: https://orcid.org/0000-0003-0930-7706 2015. P2X7 receptor activation regulates rapid unconventional export of transglutaminase-2. Journal of Cell Science 128 (24) , pp. 4615-4628. 10.1242/jcs.175968

Howes, Joanna-Marie, Pugh, Nicholas, Knauper, Vera ORCID: https://orcid.org/0000-0002-3965-9924 and Farndale, Richard W. 2015. Modified platelet deposition on MMP-13 digested collagen I. Journal of Thrombosis and Haemostatis 13 (12) , pp. 2253-2259. 10.1111/jth.13166

Wanger, Tim M., Dewitt, Sharon ORCID: https://orcid.org/0000-0001-8169-8241, Collins, Anne, Maitland, Norman J., Poghosyan, Zaruhi and Knauper, Vera ORCID: https://orcid.org/0000-0002-3965-9924 2015. Differential regulation of TROP2 release by PKC isoforms through vesicles and ADAM17. Cellular Signalling 27 (7) , pp. 1325-1335. 10.1016/j.cellsig.2015.03.017

Muller, Anne, Leinweber, Brinja, Fischer, Jana, Muller, Timo D., Gruters, Annette, Tschop, Matthias H., Knauper, Vera ORCID: https://orcid.org/0000-0002-3965-9924, Biebermann, Heike and Kleinau, Gunnar 2014. The extracellular N-terminal domain of G-protein coupled receptor 83 regulates signaling properties and is an intramolecular inverse agonist. BMC Research Notes 7 , 913. 10.1186/1756-0500-7-913

Howes, Joanna-Marie, Bihan, Dominique, Slatter, David A., Hamaia, Samir W., Packman, Len C., Knauper, Vera ORCID: https://orcid.org/0000-0002-3965-9924, Visse, Robert and Farndale, Richard W. 2014. The recognition of collagen and triple-helical toolkit peptides by MMP-13: sequence specificity for binding and cleavage. Journal of Biological Chemistry 289 , pp. 24091-24101. 10.1074/jbc.M114.583443

Qi, Jian Hua, Ebrahem, Quteba, Ali, Mariya, Cutler, Alecia, Bell, Brent, Prayson, Nicholas, Sears, Jonathan, Knauper, Vera ORCID: https://orcid.org/0000-0002-3965-9924, Murphy, Gillian and Anand-Apte, Bela 2013. Tissue inhibitor of metalloproteinases-3 peptides inhibit angiogenesis and choroidal neovascularization in mice. PLoS ONE 8 (3) , e55667. 10.1371/journal.pone.0055667

Knauper, Vera ORCID: https://orcid.org/0000-0002-3965-9924 and Murphy, Gillian 2010. Methods for studying activation of matrix metalloproteinases. Methods Mol Biol 622 , pp. 233-43. 10.1007/978-1-60327-299-5_14

Ali, N., Fiedler, L. and Knauper, Vera Louise Frieda ORCID: https://orcid.org/0000-0002-3965-9924 2009. ADAMTS4 mediated signalling alters cell morphology and motility. International Journal of Experimental Pathology 90 (1) , A60-A61.

Ali, Nazim and Knauper, Vera ORCID: https://orcid.org/0000-0002-3965-9924 2007. Phorbol Ester-induced shedding of the prostate cancer marker transmembrane protein with epidermal growth factor and two follistatin motifs 2 is mediated by the disintegrin and metalloproteinase-17*. Journal of Biological Chemistry 282 (52) , pp. 37378-37388. 10.1074/jbc.M702170200

Singh, Robert J.R., Mason, Justin C., Lidington, Elaine A., Edwards, Dylan R., Nuttall, Robert K., Khokha, Rama, Knauper, Vera ORCID: https://orcid.org/0000-0002-3965-9924, Murphy, Gillian and Gavrilovic, Jelena 2005. Cytokine stimulated vascular cell adhesion molecule-1 (VCAM-1) ectodomain release is regulated by TIMP-3. Cardiovascular Research 67 (1) , pp. 39-49. 10.1016/j.cardiores.2005.02.020

Lee, Meng-Huee, Rapti, Magdalini, Knauper, Vera ORCID: https://orcid.org/0000-0002-3965-9924 and Murphy, Gillian 2004. Threonine 98, the pivotal residue of tissue inhibitor of metalloproteinases (TIMP)-1 in metalloproteinase recognition. Journal of Biological Chemistry 279 (17) , pp. 17562-17569. 10.1074/jbc.M312589200

Murphy, Gillian, Knäuper, Vera ORCID: https://orcid.org/0000-0002-3965-9924, Meng-Huee, Lee, Amour, Augustin, Worley, Joanna R., Hutton, Mike, Atkinson, Susan, Rapti, Magdalene and Williamson, Richard 2003. Role of TIMPs (tissue inhibitors of metalloproteinases) in pericellular proteolysis:tThe specificity is in the detail. Biochemical Society Symposia 70 , pp. 65-80. 10.1042/bss0700065

Worley, Joanna R., Thompkins, Philip B., Lee, Meng H., Hutton, Mike, Soloway, Paul, Edwards, Dylan R., Murphy, Gillian and Knauper, Vera ORCID: https://orcid.org/0000-0002-3965-9924 2003. Sequence motifs of tissue inhibitor of metalloproteinases 2 (TIMP-2) determining progelatinase A (proMMP-2) binding and activation by membrane-type metalloproteinase 1 (MT1-MMP). Biochemical Journal 372 (3) , pp. 799-809. 10.1042/BJ20021573

Lee, Meng-Huee, Dodds, Philippa, Verma, Vandana, Maskos, Klaus, Knauper, Vera ORCID: https://orcid.org/0000-0002-3965-9924 and Murphy, Gillian 2003. Tailoring tissue inhibitor of metalloproteinases-3 to overcome the weakening effects of the cysteine-rich domains of tumour necrosis factor-α converting enzyme. Biochemical Journal 371 (2) , pp. 369-376. 10.1042/bj20021538

Knauper, Vera ORCID: https://orcid.org/0000-0002-3965-9924, Bailey, Louise, Worley, Joanna R., Soloway, Paul, Patterson, Margaret L. and Murphy, Gillian 2002. Cellular activation of proMMP-13 by MT1-MMP depends on the C-terminal domain of MMP-13. FEBS Letters 532 (1-2) , pp. 127-130. 10.1016/S0014-5793(02)03654-2

Lee, Meng-Huee, Maskos, Klaus, Knauper, Vera ORCID: https://orcid.org/0000-0002-3965-9924, Dodds, Philippa and Murphy, Gillian 2002. Mapping and characterization of the functional epitopes of tissue inhibitor of metalloproteinases (TIMP)-3 using TIMP-1 as the scaffold: a new frontier in TIMP engineering. Protein Science 11 (10) , pp. 2493-2503. 10.1110/ps.0216202

Lafleur, Marc A., Handsley, Madeleine M., Knauper, Vera ORCID: https://orcid.org/0000-0002-3965-9924, Murphy, Gillian and Edwards, Dylan R. 2002. Endothelial tubulogenesis within fibrin gels specifically requires the activity of membrane-type-matrix metalloproteinases (MT-MMPs). Journal of Cell Science 115 (17) , pp. 3427-3438.

Amour, Augustin, Knight, C. Graham, English, William R., Webster, Ailsa, Slocombe, Patrick M., Knauper, Vera ORCID: https://orcid.org/0000-0002-3965-9924, Docherty, Andrew J. P., Becherer, J. David, Blobel, Carl P. and Murphy, Gillian 2002. The enzymatic activity of ADAM8 and ADAM9 is not regulated by TIMPs. FEBS Letters 524 (1-3) , pp. 154-158. 10.1016/S0014-5793(02)03047-8

Lee, Meng-Huee, Verma, Vandana, Maskos, Klaus, Becherer, J. David, Knauper, Vera ORCID: https://orcid.org/0000-0002-3965-9924, Dodds, Philippa, Amour, Augustin and Murphy, Gillian 2002. The C-terminal domains of TACE weaken the inhibitory action of N-TIMP-3. FEBS Letters 520 (1-3) , pp. 102-106. 10.1016/S0014-5793(02)02776-X

Lee, Meng-Huee, Verma, Vandana, Maskos, Klaus, Nath, Deepa, Knauper, Vera ORCID: https://orcid.org/0000-0002-3965-9924, Dodds, Philippa, Amour, Augustin and Murphy, Gillian 2002. Engineering N-terminal domain of tissue inhibitor of metalloproteinase (TIMP)-3 to be a better inhibitor against tumour necrosis factor-a-converting enzyme. Biochemical Journal -London- 364 , pp. 227-234.

Stringa, E., White, D., Tuan, R. S., Knauper, Vera ORCID: https://orcid.org/0000-0002-3965-9924 and Gavrilovic, J. 2002. Role of newly synthesized fibronectin in vascular smooth muscle cell migration on matrix-metalloproteinase-degraded collagen. Biochemical Society Transactions 30 , pp. 102-111.

Rodriguez-Manzaneque, Juan Carlos, Westling, Jennifer, Thai, Shelley N. M., Luque, Alfonso, Knauper, Vera ORCID: https://orcid.org/0000-0002-3965-9924, Murphy, Gillian, Sandy, John D. and Iruela-Arispe, M. Luisa 2002. ADAMTS1 cleaves aggrecan at multiple sites and is differentially inhibited by metalloproteinase inhibitors. Biochemical and Biophysical Research Communications 293 (1) , pp. 501-508. 10.1016/S0006-291X(02)00254-1

Bailey, Louise, Wienke, Dirk, Howard, Matthew, Knauper, Vera ORCID: https://orcid.org/0000-0002-3965-9924, Isacke, Clare M. and Murphy, Gillian 2002. Investigation of the role of Endo180/urokinase-type plasminogen activator receptor-associated protein as a collagenase 3 (matrix metalloproteinase 13) receptor. Biochemical Journal -London- 363 (1) , pp. 67-72.

English, William R., Holtz, Beatrice, Vogt, Gavin, Knauper, Vera ORCID: https://orcid.org/0000-0002-3965-9924 and Murphy, Gillian 2001. Characterization of the role of the "MT-loop" - an eight-amino acid insertion specific to progelatinase A (MMP2) activating membrane-type matrix metalloproteinases. Journal of Biological Chemistry 276 (45) , pp. 42018-42026. 10.1074/jbc.M107783200

Patterson, Margaret L, Atkinson, Susan J., Knauper, Vera ORCID: https://orcid.org/0000-0002-3965-9924 and Murphy, Gillian 2001. Specific collagenolysis by gelatinase A, MMP-2, is determined by the hemopexin domain and not the fibronectin-like domain. FEBS Letters 503 (2-3) , pp. 158-162. 10.1016/S0014-5793(01)02723-5

Williamson, Richard A., Hutton, Mike, Vogt, Gavin, Rapti, Magdalene, Knauper, Vera ORCID: https://orcid.org/0000-0002-3965-9924, Carr, Mark D. and Murphy, Gillian 2001. Tyrosine 36 plays a critical role in the interaction of the AB loop of tissue inhibitor of metalloproteinases-2 with matrix metalloproteinase-14. Journal of Biological Chemistry 276 (35) , pp. 32966-32970. 10.1074/jbc.M101843200

Groft, L. L., Muzik, H., Johnston, R. N., Knauper, Vera ORCID: https://orcid.org/0000-0002-3965-9924, Lafleur, M. A., Forsyth, P. A. and Edwards, D. R. 2001. Differential expression and localization of TIMP-1 and TIMP-4 in human gliomas. British Journal of Cancer 85 (1) , pp. 55-63. 10.1054/bjoc.2001.1854

Lafleur, Marc A., Hollenberg, Morley D., Atkinson, Susan J., Knauper, Vera ORCID: https://orcid.org/0000-0002-3965-9924, Murphy, Gillian and Edwards, Dylan R. 2001. Activation of pro-(matrix metalloproteinase-2) (pro-MMP-2) by thrombin is membrane-type-MMP-dependent in human umbilical vein endothelial cells and generates a distinct 63 kDa active species. Biochemical Journal 357 (1) , pp. 107-115. 10.1042/bj3570107

Knauper, Vera ORCID: https://orcid.org/0000-0002-3965-9924, Balbin, M, Fueyo, A and Lopez-Otin, C 2001. Identification and enzymatic characterization of two diverging murine counterparts of human interstitial collagenase (MMP-1) expressed at sites of embryo implantation. Journal of Biological Chemistry 276 (13) , pp. 10253-10262.

Knauper, Vera ORCID: https://orcid.org/0000-0002-3965-9924, Patterson, Margaret L., Gomis-Ruth, Franz X., Smith, Bryan, Lyons, Alan, Docherty, Andrew J.P. and Murphy, Gillian 2001. The role of exon 5 in fibroblast collagenase (MMP-1) substrate specificity and inhibitor selectivity. European Journal of Biochemistry 268 (6) , pp. 1888-1896. 10.1046/j.1432-1327.2001.02062.x

Lee, Meng-Huee, Knauper, Vera ORCID: https://orcid.org/0000-0002-3965-9924, Becherer, J.David and Murphy, Gillian 2001. Full-length and N-TIMP-3 display equal inhibitory activities toward TNF-α convertase. Biochemical and Biophysical Research Communications 280 (3) , pp. 945-950. 10.1006/bbrc.2000.4192

Bond, Mark, Murphy, Gillian, Bennett, Martin R, Amour, Augustin, Knauper, Vera ORCID: https://orcid.org/0000-0002-3965-9924, Newby, Andrew C. and Baker, Andrew H. 2000. Localization of the death domain of tissue inhibitor of metalloproteinase-3 to the N terminus: Metalloproteinase inhibition is associated with proapoptotic activity. Journal of Biological Chemistry 275 (52) , pp. 41358-41363. 10.1074/jbc.M007929200

Wang, Ting, Aoki, Takanori, Iwata, Kazushi, Takata, Takashi, Uchida, Takashi, Knauper, Vera ORCID: https://orcid.org/0000-0002-3965-9924, Llano, Elena, Okada, Yasunori and Bartlett, John D. 2000. One-step sandwich enzyme immunoassay using monoclonal antibodies for detection of human enamelysin (MMP-20). European Journal of Oral Sciences 108 (6) , pp. 530-537. 10.1034/j.1600-0722.2000.00922.x

Stracke, Jan O., Fosang, Amanda J., Last, Karena, Mercuri, Francesca A., Pendás, Alberto M., Llano, Elena, Perris, Roberto, Di Cesare, Paul E., Murphy, Gillian and Knauper, Vera ORCID: https://orcid.org/0000-0002-3965-9924 2000. Matrix metalloproteinases 19 and 20 cleave aggrecan and cartilage oligomeric matrix protein (COMP). FEBS Letters 478 (1-2) , pp. 52-56. 10.1016/S0014-5793(00)01819-6

Hardern, Ian M., Knauper, Vera ORCID: https://orcid.org/0000-0002-3965-9924, Ernill, Richard J., Taylor, Ian W.F., Cooper, Katy L. and Abbott, W.Mark 2000. An analysis of two refolding routes for a C-terminally truncated human collagenase-3 expressed in Escherichia coli. Protein Expression and Purification 19 (2) , pp. 246-252. 10.1006/prep.2000.1244

Stringa, Emanuela, Knauper, Vera ORCID: https://orcid.org/0000-0002-3965-9924, Murphy, Gillian and Gavrilovic, Jelena 2000. Collagen degradation and platelet-derived growth factor stimulate the migration of vascular smooth muscle cells. Journal of Cell Science 113 (11) , pp. 2055-2064. 10.1242/jcs.113.11.2055

Amour, Augustin, Knight, C.Graham, Webster, Ailsa, Slocombe, Patrick M., Stephens, Paul E., Knauper, Vera ORCID: https://orcid.org/0000-0002-3965-9924, Docherty, Andrew J.P. and Murphy, Gillian 2000. The in vitro activity of ADAM-10 is inhibited by TIMP-1 and TIMP-3. FEBS Letters 473 (3) , pp. 275-279. 10.1016/S0014-5793(00)01528-3

Stracke, Jan O., Hutton, Mike, Stewart, Margaret, Pendás, Alberto M., Smith, Bryan, López-Otin, Carlos, Murphy, Gillian and Knauper, Vera ORCID: https://orcid.org/0000-0002-3965-9924 2000. Biochemical characterization of the catalytic domain of human matrix metalloproteinase 19. Evidence for a role as a potent basement membrane degrading enzyme. Journal of Biological Chemistry 275 (20) , pp. 14809-14816. 10.1074/jbc.275.20.14809

English, William R., Puente, Xose S., Freije, José M.P., Knauper, Vera ORCID: https://orcid.org/0000-0002-3965-9924, Amour, Augustin, Merryweather, Ann, López-Otı́n, Carlos and Murphy, Gillian 2000. Membrane type 4 matrix metalloproteinase (MMP17) has tumor necrosis factor-α convertase activity but does not activate pro-MMP2. Journal of Biological Chemistry 275 (19) , pp. 14046-14055. 10.1074/jbc.275.19.14046

Murphy, G., Knauper, V. ORCID: https://orcid.org/0000-0002-3965-9924, Atkinson, S., Gavrilovic, J. and Edwards, D. 2000. Cellular mechanisms for focal proteolysis and the regulation of the microenvironment. Fibrinolysis and Proteolysis 14 (2-3) , pp. 165-174. 10.1054/fipr.2000.0068

Ottl, J., Gabriel, D., Murphy, G., Knauper, Vera ORCID: https://orcid.org/0000-0002-3965-9924, Tominaga, Y., Nagase, H., Kröger, M., Tschesche, H., Bode, W. and Moroder, L. 2000. Recognition and catabolism of synthetic heterotrimeric collagen peptides by matrix metalloproteinases. Chemistry and Biology 7 (2) , pp. 119-132. 10.1016/S1074-5521(00)00077-6

Butler, Georgina S., Hutton, Mike, Wattam, Beth A., Williamson, Richard A., Knauper, Vera ORCID: https://orcid.org/0000-0002-3965-9924, Willenbrock, Frances and Murphy, Gillian 1999. The specificity of TIMP-2 for matrix metalloproteinases can be modified by single amino acid mutations. Journal of Biological Chemistry 274 (29) , pp. 20391-20396. 10.1074/jbc.274.29.20391

Vassiliou, Stamatia, Mucha, Artur, Cuniasse, Philippe, Georgiadis, Dimitris, Lucet-Levannier, Karine, Beau, Fabrice, Kannan, Rama, Murphy, Gillian, Knauper, Vera ORCID: https://orcid.org/0000-0002-3965-9924, Rio, Marie-Christine, Basset, Paul, Yiotakis, Athanasios and Dive, Vincent 1999. Phosphinic pseudo-tripeptides as potent inhibitors of matrix metalloproteinases: a structure-activity study. Journal of Medicinal Chemistry 42 (14) , pp. 2610-2620. 10.1021/jm9900164

Amour, Augustin, Hutton, Mike, Knaüper, Vera ORCID: https://orcid.org/0000-0002-3965-9924, Slocombe, Patrick M., Webster, Ailsa, Butler, Michael, C. Graham, Knight, Smith, Bryan J., Docherty, Andrew J.P. and Murphy, Gillian 1999. Inhibition of the metalloproteinase domain of mouse TACE. Annals of the New York Academy of Sciences 878 (1) , pp. 728-731. 10.1111/j.1749-6632.1999.tb07774.x

Murphy, Gillian, Knäuper, Vera ORCID: https://orcid.org/0000-0002-3965-9924, Cowell, Susan, Stanton, Heather, Butler, Georgina, Freije, Jose, Pendas, Alberto M., Lopez-Otin, Carlos and Hembrey, Rosalind 1999. Evaluation of some newer matrix metalloproteinases. Annals of the New York Academy of Sciences 878 (1) , pp. 25-39. 10.1111/j.1749-6632.1999.tb07672.x

Llano, Elena, Pendás, Alberto M, Freije, Jose P, Nakano, Atsuhisa, Knauper, Vera ORCID: https://orcid.org/0000-0002-3965-9924, Murphy, Gillian and López-Otin, Carlos 1999. Identification and characterization of human MT5-MMP, a new membrane- bound activator of progelatinase A overexpressed in brain tumors. Cancer Research 59 (11) , pp. 2570-2576.

Murphy, Gillian, Stanton, Heather, Cowell, Susan, Butler, Georgina, Knauper, Vera ORCID: https://orcid.org/0000-0002-3965-9924, Susan, Atkinson and Gavrilovic, Jelena 1999. Mechanisms for pro matrix metalloproteinase activation. APMIS 107 (1-6) , pp. 38-44. 10.1111/j.1699-0463.1999.tb01524.x

Amour, Augustin, Slocombe, Patrick M, Webster, Ailsa, Butler, Michael, Knight, C.Graham, Smith, Bryan J, Stephens, Paul E, Shelley, Chris, Hutton, Mike, Knauper, Vera ORCID: https://orcid.org/0000-0002-3965-9924, Docherty, Andrew J.P and Murphy, Gillian 1998. TNF-α converting enzyme (TACE) is inhibited by TIMP-3. FEBS Letters 435 (1) , pp. 39-44. 10.1016/S0014-5793(98)01031-X

Messent, Anthea J., Tuckwell, Danny S., Knauper, Vera ORCID: https://orcid.org/0000-0002-3965-9924, Humphries, Martin J., Murphy, Gillian and Gavrilovic, Jelena 1998. Effects of collagenase-cleavage of type I collagen on α2β1 integrin-mediated cell adhesion. Journal of Cell Science 111 (8) , pp. 1127-1135. 10.1242/jcs.111.8.1127

Cowell, Susan, Knauper, Vera ORCID: https://orcid.org/0000-0002-3965-9924, Stewart, Margaret L., D'ortho, Marie-Pia, Stanton, Heather, Hembrey, Rosalind M., López-Otín, Carlos, Reynolds, John J. and Murphy, Gillian 1998. Induction of matrix metalloproteinase activation cascades based on membrane-type 1 matrix metalloproteinase: Associated activation of gelatinase A, gelatinase B and collagenase 3. Biochemical Journal 331 (2) , pp. 453-458. 10.1042/bj3310453

Llano, Elena, Pendás, Alberto M., Knauper, Vera ORCID: https://orcid.org/0000-0002-3965-9924, Sorsa, Timo, Salo, Tuula, Salido, Eduardo, Murphy, Gillian, Simmer, James P., Bartlett, John D. and López-Otín, Carlos 1997. Identification and structural and functional characterization of human enamelysin (MMP-20). Biochemistry 36 (49) , pp. 15101-15108. 10.1021/bi972120y

Knauper, Vera ORCID: https://orcid.org/0000-0002-3965-9924, Smith, Bryan, López-Otin, Carlos and Murphy, Gillian 1997. Activation of progelatinase B (proMMP-9) by active collagenase-3 (MMP-13). European Journal of Biochemistry 248 (2) , pp. 369-373. 10.1111/j.1432-1033.1997.00369.x

Sasaki, Takako, Göhring, Walter, Mann, Karlheinz, Maurer, Patrik, Hohenester, Erhard, Knauper, Vera ORCID: https://orcid.org/0000-0002-3965-9924, Murphy, Gillian and Timpl, Rupert 1997. Limited cleavage of extracellular matrix protein BM-40 by matrix metalloproteinases increases its affinity for collagens. Journal of Biological Chemistry 272 (14) , pp. 9237-9243. 10.1074/jbc.272.14.9237

Murphy, Gillian and Knauper, Vera ORCID: https://orcid.org/0000-0002-3965-9924 1997. Relating matrix metalloproteinase structure to function: Why the 'Hemopexin' domain? Matrix Biology 15 (8-9) , pp. 511-518. 10.1016/S0945-053X(97)90025-1

Knauper, Vera ORCID: https://orcid.org/0000-0002-3965-9924, Cowell, Susan, Smith, Bryan, López-Otin, Carlos, O'Shea, Mark, Morris, Helen, Zardi, Luciano and Murphy, Gillian 1997. The role of the C-terminal domain of human collagenase-3 (MMP-13) in the activation of procollagenase-3, substrate specificity, and tissue inhibitor of metalloproteinase interaction. Journal of Biological Chemistry 272 (12) , pp. 7608-7616. 10.1074/jbc.272.12.7608

Knauper, Vera ORCID: https://orcid.org/0000-0002-3965-9924, Docherty, Andrew J.P, Smith, Bryan, Tschesche, Harald and Murphy, Gillian 1997. Analysis of the contribution of the hinge region of human neutrophil collagenase (HNC, MMP-8) to stability and collagenolytic activity by alanine scanning mutagenesis. FEBS Letters 405 (1) , pp. 60-64. 10.1016/S0014-5793(97)00158-0

Pendás, Alberto M, Knauper, Vera ORCID: https://orcid.org/0000-0002-3965-9924, Puente, Xose S., Llano, Elena, Mattei, Marie-Genevieve, Apte, Suneel, Murphy, Gillian and López-Otín, Carlos 1997. Identification and characterization of a novel human matrix metalloproteinase with unique structural characteristics, chromosomal location, and tissue distribution. Journal of Biological Chemistry 272 (7) , pp. 4281-4286. 10.1074/jbc.272.7.4281

Gomis-Rüth, F.X., Gohlke, U., Betz, M., Knauper, Vera ORCID: https://orcid.org/0000-0002-3965-9924, Murphy, G., López-Otı́n, C. and Bode, W. 1996. The helping hand of collagenase-3 (MMP-13): 2.7 Å crystal structure of its C-terminal haemopexin-like domain. Journal of Molecular Biology 264 (3) , pp. 556-566. 10.1006/jmbi.1996.0661

Fosang, Amanda J., Last, Karena, Knauper, Vera ORCID: https://orcid.org/0000-0002-3965-9924, Murphy, Gillian and Neame, Peter J. 1996. Degradation of cartilage aggrecan by collagenase-3 (MMP-13). FEBS Letters 380 (1-2) , pp. 17-20. 10.1016/0014-5793(95)01539-6

Matsuki, Hirokazu, Fujimoto, Noboru, Iwata, Kazushi, Knauper, Vera ORCID: https://orcid.org/0000-0002-3965-9924, Okada, Yasunori and Hayakawa, Taro 1996. A one-step sandwich enzyme immunoassay for human matrix metalloproteinase 8 (neutrophil collagenase) using monoclonal antibodies. Clinica Chimica Acta 244 (2) , pp. 129-143. 10.1016/0009-8981(95)06197-5

Knauper, Vera ORCID: https://orcid.org/0000-0002-3965-9924, López-Otin, Carlos, Smith, Bryan, Knight, Graham and Murphy, Gillian 1996. Biochemical characterization of human collagenase-3. Journal of Biological Chemistry 271 (3) , pp. 1544-1550. 10.1074/jbc.271.3.1544

Knauper, Vera ORCID: https://orcid.org/0000-0002-3965-9924, Murphy, Gillian and Tschesche, Harald 1996. Activation of human neutrophil procollagenase by stromelysin 2. European Journal of Biochemistry 235 (1-2) , pp. 187-191. 10.1111/j.1432-1033.1996.00187.x

Siri, Annalisa, Knauper, Vera ORCID: https://orcid.org/0000-0002-3965-9924, Veirana, Natalia, Caocci, Fabio, Murphy, Gillian and Zardi, Luciano 1995. Different susceptibility of small and large human tenascin-C isoforms to degradation by matrix metalloproteinases. Journal of Biological Chemistry 270 (15) , pp. 8650-8654. 10.1074/jbc.270.15.8650

Fosang, A J, Last, K, Neame, P J, Murphy, G, Knauper, Vera ORCID: https://orcid.org/0000-0002-3965-9924, Tschesche, H, Hughes, C E, Caterson, B and Hardingham, T E 1994. Neutrophil collagenase (MMP-8) cleaves at the aggrecanase site E373-A(374) in the interglobular domain of cartilage aggrecan. Biochemical Journal 304 (2) , pp. 347-351. 10.1042/bj3040347

Knauper, Vera ORCID: https://orcid.org/0000-0002-3965-9924, Murphy, Gillian and Tschesche, Harald 1994. Neutrophil procollagenase can be activated by stromelysin-2. Annals of the New York Academy of Sciences 732 (1) , pp. 367-368. 10.1111/j.1749-6632.1994.tb24755.x

Barnes Jr., Eugene M., Calkin, Patricia A., Kuroda, Satoshi, Norioka, Shigemi, Mitta, Masanori, Kato, Ikunoshin, Sakiyama, Fumio, Nika, Heinz, Chow, David T., Hess, Daniel, Bures, Edward J., Morrison, Hamish D., Aebersold, Ruedi, Clore, G. Marius, Gronenborn, Angela M., Persson, Bengt, Argos, Patrick, James, Peter, Cannons, Andrew C., Solomonson, Larry P., Dombrowski, Kenneth E., Moddeman, William E., Wright, Stephen E., Barker, Winona C., George, David G., Mattagajasingh, Subhendra N., Misra, Hara P., Huang, Shuan Shian, Huang, Jung San, Lee, Y. C., Fischer, Wolfgang H., Craig, A. Grey, McFadden, Philip N., Lind-quist, Jonathan A., Bartlet-Jones, M., Jeffery, W., Hansen, H. F., Pappin, D. J. C., Bergman, Tomas, Hjelmqvist, Lars, Estonius, Mats, Jörnvall, Hans, Dorow, Donna S., Tschesche, H., Knauper, Vera ORCID: https://orcid.org/0000-0002-3965-9924, Kleine, T., Reinemer, P., Schnierer, S., Grams, F., Bode, W., Southan, Christopher, Fantom, Kenneth, Lavery, Patric, Findlay, J. B. C., Akrigg, D., Attwood, T. K., Beck, M. J., Bleasby, A. J., North, A. C. T., Parry-Smith, D. J., Perkins, D. N., Aitken, A., Patel, Y., Martin, H., Jones, D., Robinson, K., Madrazo, J., Howell, S., Aebersold, Ruedi, Hess, Daniel, Yungwirth, Tom, Affolter, Michael, Amankwa, Lawrence, Scheraga, Harold A., Yang, Chao -Yuh, Valentinova, Natalia V., Yang, Manlan, Gu, Zi -Wei, Gotto Jr., Antonio M., Dovichi, Norman J., Waldron, Karen C., Chen, Min, Ireland, Ian, Omori, Akira, Yoshida, Sachiyo, Schaller, Johann, Lengweiler, Stephan, Rickli, Egon E., Bubis, José, Ortiz, Julio O., Möller, Carolina, Millán, Enrique J., Boyd, Victoria L., Bozzini, MeriLisa, Zhao, Jindong, DeFranco, Robert J., Yuan, Pau -Miau, Loudon, G. Marc, Nguyen, Duy, Kamo, Masaharu, Kawakami, Takao, Miyatake, Norifumi, Tsugita, Akira, Kamo, Masaharu, Takamoto, Keiji, Satake, Kazuo, Bischof, Oliver, Hechenberger, Mirko, Thiede, Bernd, Kruft, Volker, Wittmann-Liebold, Brigitte, Otto, Albrecht, Benndorf, Rainer, Jungblut, Peter, Ühlein, Monika, Urlaub, Henning, Berhardt, Rita, Kraft, Regine, Uhlmann, Heike, Beckert, Vita, Akizawa, Toshifumi, Ayabe, Takaaki, Matsukawa, Motomi, Itoh, Michiyasu, Nishi, Masatoshi, Sato, Hiroshi, Seiki, Motoharu, Yoshioka, Masanori, Lebl, Michal, Krchňák, Viktor, Sepetov, Nikolai F., Kočiš, Petr, Pátek, Marcel, Flegelová, Zuzana, Ferguson, Ronald, Lam, Kit S., Moritz, Robert L., Eddes, James, Ji, Hong, Reid, Gavin E., Simpson, Richard J., Seffens, William, Poulter, C. Dale, Dolence, Julia M., Bond, Pamela D., Nokihara, Kiyoshi, Ikegaya, Kazuo, Morita, Naoki, Ohmura, Takao, Salikhov, S. I., Sagdiev, N. J., Korneev, A. S., Dolimbek, Behzod Z., Atassi, M. Zhouhair, Rosenberg, J. S., Yun, Z., Wyde, P. R., Atassi, M. Z., Gaskell, Simon J., Anumula, Kalyan Rao, Goldenberg, David P., Appella, Ettore, Fiscella, Michelle, Zambrano, Nicola, Ullrich, Stephen J., Sakaguchi, Kazuyasu, Sakamoto, Hiroshi, Lewis, Marc S., Lin, David, Mercer, W. Edward, Anderson, Carl W., Connelly, Marjorie A., Zhang, Hong, Sipley, John D., Lees-Miller, Susan P., Sakaguchi, Kazuyasu, Jackson, Stephen P., Xie, Yong-hong, Yang, Manlan, Quion, Jun A., Yang, Chao-yuh, Brandt, W. F., Alk, H., Bhaskaran, R., Yu, Chin, Yang, C. C., Henschen, Agnes H., Ashman, Keith, Mann, Matthias, Guevara Jr., Juan, Nguyen, Hung Michael, Davison, Daniel B., Morrisett, Joel D., Perham, Richard N., Marvin, Donald A., Symmons, Martyn F., Terry, Tamsin D., Beg, Z. H., Stonik, J. A., Hoeg, J. M., Brewer Jr., H. B., Gorovits, Boris M., Raman, C. S. and Horowtiz, Paul M. 1994. MPSA short communications. Journal of Protein Chemistry 13 (5) , pp. 431-512. 10.1007/BF01898855

Tschesche, H., Knauper, V. ORCID: https://orcid.org/0000-0002-3965-9924, Kleine, T., Reinemer, P., Schnierer, S., Grams, F. and Bode, W. 1994. Function and structure of human leucocyte collagenase. Protein Journal 13 (5) , pp. 460-461. 10.1007/978-1-4899-1031-8_34

Knauper, V ORCID: https://orcid.org/0000-0002-3965-9924, Wilhelm, S, Seperack, P K, DeClerck, Y A, Langley, K E, Osthues, A and Tschesche, H 1993. Direct activation of human neutrophil procollagenase by recombinant stromelysin. Biochemical Journal 295 (2) , pp. 581-586. 10.1042/bj2950581

Fosang, A J, Last, K, Knauper, V ORCID: https://orcid.org/0000-0002-3965-9924, Neame, P J, Murphy, G, Hardingham, T E, Tschesche, H and Hamilton, J A 1993. Fibroblast and neutrophil collagenases cleave at two sites in the cartilage aggrecan interglobular domain. Biochemical Journal 295 (1) , pp. 273-276. 10.1042/bj2950273

Knauper, V ORCID: https://orcid.org/0000-0002-3965-9924, Osthues, A, DeClerck, Y A, Langley, K E, Bläser, J and Tschesche, H 1993. Fragmentation of human polymorphonuclear-leucocyte collagenase. Biochemical Journal 291 (3) , pp. 847-854. 10.1042/bj2910847

Schnierer, S., Kleine, T., Gote, T., Hillemann, A., Knauper, V. ORCID: https://orcid.org/0000-0002-3965-9924 and Tschesche, H. 1993. The recombinant catalytic domain of human neutrophil collagenase lacks type I collagen substrate specificity. Biochemical and Biophysical Research Communications 191 (2) , pp. 319-326. 10.1006/bbrc.1993.1220

Triebel, Susanne, Bläser, Jörg, Reinke, Heinz, Knauper, Vera ORCID: https://orcid.org/0000-0002-3965-9924 and Tschesche, Harald 1992. Mercurial activation of human PMN leucocyte type IV procollagenase (gelatinase). FEBS Letters 298 (2-3) , pp. 280-284. 10.1016/0014-5793(92)80077-T

Osthues, Anja, Knauper, Vera ORCID: https://orcid.org/0000-0002-3965-9924, Oberhoff, Renate, Reinke, Heinz and Tschesche, Harald 1992. Isolation and characterization of tissue inhibitors of metalloproteinases (TIMP-1 and TIMP-2) from human rheumatoid synovial fluid. FEBS Letters 296 (1) , pp. 16-20. 10.1016/0014-5793(92)80393-U

Tschesche, H., Knauper, Vera ORCID: https://orcid.org/0000-0002-3965-9924, Krämer, S., Michaelis, J., Oberhoff, R. and Reinke, H. 1992. Latent collagenase and gelatinase from human neutrophils and their activation. Matrix (Stuttgart, Germany). Supplement 1 , pp. 245-255.

Blaser, Jörg, Knauper, Vera ORCID: https://orcid.org/0000-0002-3965-9924, Osthues, Anja, Reinke, Heinz and Tschesche, Harald 1991. Mercurial activation of human polymorphonuclear leucocyte procollagenase. European Journal of Biochemistry 202 (3) , pp. 1223-1230. 10.1111/j.1432-1033.1991.tb16494.x

Knauper, Vera ORCID: https://orcid.org/0000-0002-3965-9924, Triebel, Susanne, Reinke, Heinz and Tschesche, Harald 1991. Inactivation of human plasma C1-inhibitor by human PMN leucocyte matrix metalloproteinases. FEBS Letters 290 (1-2) , pp. 99-102. 10.1016/0014-5793(91)81235-Z

Knauper, V ORCID: https://orcid.org/0000-0002-3965-9924, Kramer, S, Reinke, H and Tschesche, H 1990. Partial amino acid sequence of human PMN leukocyte procollagenase. Biological Chemistry Hoppe-Seyler 371 (5 SUPP) , pp. 295-304. 10.1515/bchm3.1990.371.2.733

Knauper, Vera ORCID: https://orcid.org/0000-0002-3965-9924, Kramer, S., Reinke, H. and Tschesche, H. 1990. Partial amino-acid sequence of human PMN leukocyte procollagenase. Biological Chemistry Hoppe Seyler 371 (8) , p. 733.

Knauper, Vera ORCID: https://orcid.org/0000-0002-3965-9924, Kramer, Silke, Reinke, Heinz and Tscheche, Harald 1990. Characterization and activation of procollagenase from human polymorphonuclear leucocytes. N-terminal sequence determination of the proenzyme and various proteolytically activated forms. European Journal of Biochemistry 189 (2) , pp. 295-300. 10.1111/j.1432-1033.1990.tb15489.x

Knauper, Vera ORCID: https://orcid.org/0000-0002-3965-9924, Reinke, Heinz and Tschesche, Harald 1990. Inactivation of human plasma α1-proteinase inhibitor by human PMN leucocyte collagenase. FEBS Letters 263 (2) , pp. 355-357. 10.1016/0014-5793(90)81412-H

Wize, J, Knauper, V ORCID: https://orcid.org/0000-0002-3965-9924 and Tschesche, H 1990. Some properties of latent collagenase from human synovial fluid. Acta Biochimica Polonica 37 (1) , pp. 201-206.

Bergmann, U., Michaelis, J., Oberhoff, Renate, Knauper, Vera ORCID: https://orcid.org/0000-0002-3965-9924, Beckmann, R. and Tschesche, H. 1989. Enzyme linked immunosorbent assays (ELISA) for the quantitative determination of human leukocyte collagenase and gelatinase. Journal Of Clinical Chemistry And Clinical Biochemistry 27 (6) , pp. 351-359. 10.1515/cclm.1989.27.6.351