‘Waiting impulsivity’ in isolation-reared and socially-reared rats: effects of amphetamine

Liu, Yia-Ping, Wilkinson, Lawrence S. ORCID: https://orcid.org/0000-0002-9337-6124 and Robbins, Trevor W. 2017. ‘Waiting impulsivity’ in isolation-reared and socially-reared rats: effects of amphetamine. Psychopharmacology 234 (9-10) , pp. 1587-1601. 10.1007/s00213-017-4579-8

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Abstract

Background Rats reared in social isolation exhibit various cognitive and behavioural abnormalities in adulthood. However, impulsivity following this treatment still remains unclear, especially in response to medications used in attention deficit hyperactivity disorder, such as amphetamine. Methods Using an isolation-rearing (IR) manipulation, the present study examined the effects of IR on impulsive action and impulsive choice when also treated with doses of d-amphetamine, by employing the five-choice serial reaction time task (5-CSRTT) and a temporal discounting of reward task (TDRT), respectively. Results IR rats showed similar acquisition of the 5-CSRTT. Amphetamine increased premature responding in both groups; however, IR rats showed less responding overall. For the TDRT, IR rats revealed a greater preference for the large but delayed reward during task acquisition (i.e. were less impulsive) with a higher rate of nose poking during the delay, and exhibited a compressed dose-response function (i.e. reduced dose sensitivity) for amphetamine. Discussion Impulsive action and impulsive choice were reduced in IR rats under certain conditions, and a blunted response to d-amphetamine was found on these measures. These reductions in impulsivity contrast with locomotor hyperactivity normally shown in IR rats and the findings have implications for the utility of IR as a model of psychopathology.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Psychology Medicine Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	B Philosophy. Psychology. Religion > BF Psychology
Uncontrolled Keywords:	Isolation rearing Social deprivation Impulsivity Behavioural inhibition, Amphetamine, Dopamine, Five-choice serial reaction time task, Reward temporal discounting ADHD
Additional Information:	This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Publisher:	Springer Verlag
ISSN:	0033-3158
Date of First Compliant Deposit:	1 March 2017
Date of Acceptance:	20 February 2017
Last Modified:	22 May 2023 19:00
URI:	https://orca.cardiff.ac.uk/id/eprint/98657

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