TENB2, a proteoglycan identified in prostate cancer that is associated with disease progression and androgen independence

Glynne-Jones, Eveline Marie, Harper, Maureen Elaine, Seery, Liam Thomas, James, Rhianedd, Anglin, Ian Edward, Morgan, Helen E., Taylor, Kathryn Mary ORCID: https://orcid.org/0000-0002-9576-9490, Gee, Julia Margaret Wendy ORCID: https://orcid.org/0000-0001-6483-2015 and Nicholson, Robert Ian 2001. TENB2, a proteoglycan identified in prostate cancer that is associated with disease progression and androgen independence. International Journal of Cancer 94 (2) , pp. 178-184. 10.1002/ijc.1450

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Abstract

TENB2 encodes a putative transmembrane proteoglycan, related to the EGF/heregulin family of growth factors and follistatin, which has been identified through the application of a differential display technique to a xenograft model of prostate cancer. Northern analysis and competitive PCR were used to demonstrate significantly increased TENB2 expression (p = 0.0003) on the acquisition of androgen independence in the model system. TENB2 is also overexpressed in clinical prostate carcinoma vs. its benign counterpart (p < 0.0001), with particular prominence in high-grade tumours, and shows a high degree of tissue specificity, being detected on a multitissue Northern array exclusively in brain and prostate material. Studies of recombinant protein expression demonstrate that TENB2 is a chondroitin sulphate proteoglycan. The presence of an EGF and 2 follistatin domains suggests a role in the regulation of growth factor signalling either as a ligand precursor, a membrane-bound receptor or as a binding protein for growth factors. These data are indicative of a significant role for TENB2 in the progression of poorly differentiated tumour types, with implications for prostate cancer detection, prognosis and therapy.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Pharmacy
Subjects:	R Medicine > R Medicine (General)
Uncontrolled Keywords:	Androgen independence ; Differential display ; Prostate cancer ; Transmembrane protein ; EGF and follistatin modules ; Proteoglycan
ISSN:	1097-0215
Last Modified:	17 Oct 2022 08:46
URI:	https://orca.cardiff.ac.uk/id/eprint/992

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