Plasma complement biomarkers distinguish multiple sclerosis and neuromyelitis optica spectrum disorder

Hakobyan, Svetlana, Luppe, Sebastian, Evans, David R. S., Harding, Katharine, Loveless, Samantha ORCID: https://orcid.org/0000-0002-5124-4115, Robertson, Neil P. ORCID: https://orcid.org/0000-0002-5409-4909 and Morgan, Bryan Paul ORCID: https://orcid.org/0000-0003-4075-7676 2017. Plasma complement biomarkers distinguish multiple sclerosis and neuromyelitis optica spectrum disorder. Multiple Sclerosis Journal 23 (7) , pp. 946-955. 10.1177/1352458516669002

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Abstract

Background: Multiple sclerosis (MS) and neuromyelitis optica spectrum disorders (NMOSD) are autoimmune demyelinating diseases distinguished clinically by selective involvement in NMOSD of optic nerves and spinal cord. Early clinical manifestations are similar, complicating clinical management. Aquaporin-4 autoantibody measurement aids diagnosis of NMOSD but is frequently negative, creating unmet need for alternative biomarkers. Objective: We investigated whether plasma complement proteins are altered in MS and NMOSD and whether these provide biomarkers that reliably distinguish the diseases. Methods: Plasma from 53 NMOSD, 49 MS and 69 control donors was tested in multiplex assays measuring complement activation products and proteins. Logistic regression was used to test whether combinations of complement analyte measurements distinguish NMOSD from controls and MS. Results: All activation products were significantly elevated in NMOSD compared to either control or MS. Four complement proteins (C1inh, C1s, C5, FH) were significantly higher in NMOSD compared to MS or controls. A model comprising C1 inhibitor and TCC distinguished NMOSD from MS (area under curve (AUC) 0.98), while C1 inhibitor and C5 distinguished NMOSD from controls (AUC 0.94). Conclusions: NMOSD is distinguished from MS by plasma complement activation.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Subjects:	Q Science > QH Natural history > QH426 Genetics R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords:	Multiple sclerosis, neuromyelitis optica, inflammation, complement, biomarker
Publisher:	Sage
ISSN:	1352-4585
Date of First Compliant Deposit:	5 May 2017
Date of Acceptance:	19 August 2016
Last Modified:	12 Nov 2023 10:12
URI:	https://orca.cardiff.ac.uk/id/eprint/100325

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