Anti-transglutaminase 6 autoantibody development in children with celiac disease correlates with duration of gluten exposure

De Leo, Luigina, Aeschlimann, Daniel ORCID: https://orcid.org/0000-0003-0930-7706, Hadjivassiliou, Marios, Aeschlimann, Pascale, Salce, Nicola, Vatta, Serena, Ziberna, Fabiana, Cozzi, Giorgio, Martelossi, Stefano, Ventura, Alessandro and Not, Tarcisio 2018. Anti-transglutaminase 6 autoantibody development in children with celiac disease correlates with duration of gluten exposure. Journal of Pediatric Gastroenterology and Nutrition 66 (1) , pp. 64-68. 10.1097/MPG.0000000000001642

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Abstract

Objectives: Antibodies against transglutaminase 6 (anti-TG6) have been implicated in neurological manifestations in adult patients with genetic-gluten intolerance and it is unclear whether autoimmunity to TG6 develops following prolonged gluten exposure. We measured the anti-TG6 in children with celiac disease (CD) at the diagnosis time to establish a correlation between these autoantibodies and the duration of gluten exposure. We investigated a correlation between anti-TG6 and the presence of neurological disorders. Methods: Anti-TG6 (IgA/IgG) were measured by ELISA in sera of children with biopsy-proven CD and of children suffering from gastrointestinal disorders. CD-patients positive for anti-TG6 were retested after 2 years of gluten-free diet (GFD). Results: We analyzed the sera of 274 CD-children and of 121 controls. Anti-TG6 were detected in 68/274 (25%) CD-patients and in 19/121 (16%) controls, with significant difference between the two groups (p=0.04). None of the CD-patients and of the controls testing positive for anti-TG6 were suffering from neurological disorders. Eleven/18 (61%) CD-patients with other autoimmune diseases were positive for anti-TG6. In CD-patients a significant correlation between the gluten exposure before the CD-diagnosis and anti-TG6 concentration was found (p=0.006 for IgA; p<0.0001 for IgG). After GFD anti-TG6 concentrations were significantly reduced (p<0.001). No significant correlation was observed between anti-TG6 and anti-TG2 serum concentrations. Conclusions: Anti-TG6 are more prevalent in children with untreated-CD in absence of overt neurological disorders. The synthesis of the anti-TG6 are related to a longer exposure to gluten before the CD diagnosis and the autoimmunity against TG6 is gluten dependent and disappeared during GFD.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Dentistry
Subjects:	R Medicine > RJ Pediatrics R Medicine > RZ Other systems of medicine
Publisher:	Lippincott, Williams & Wilkins
ISSN:	0277-2116
Funders:	IRCCS Burlo Garofolo (Grant 03/15) Italy and Ryder Briggs Trust, UK
Date of First Compliant Deposit:	15 May 2017
Date of Acceptance:	6 May 2017
Last Modified:	09 Jan 2025 22:45
URI:	https://orca.cardiff.ac.uk/id/eprint/100399

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