Exploring multistep continuous-flow hydrosilylation reactions catalyzed by tris(pentafluorophenyl)borane

Wilkins, Lewis C., Howard, Joseph L., Burger, Stefan, Frentzel-Beyme, Louis, Browne, Duncan L. ORCID: https://orcid.org/0000-0002-8604-229X and Melen, Rebecca L. ORCID: https://orcid.org/0000-0003-3142-2831 2017. Exploring multistep continuous-flow hydrosilylation reactions catalyzed by tris(pentafluorophenyl)borane. Advanced Synthesis and Catalysis 359 (15) , pp. 2580-2584. 10.1002/adsc.201700349

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Abstract

Exploring the combination of continuous‐flow processes with the boron Lewis acid catalyzed hydrosilylation of aldehydes and ketones has delivered a robust and generally applicable reaction protocol. Notably this approach permits ready access to high temperatures and pressures and thus allows improved reactivity of substrates that were previously recalcitrant under the traditional approach. Efforts to quench the output from the flow reactor with water showed surprising tolerance leading to the application of continuous‐flow systems in multistep imine formation/hydrosilylation processes to generate the corresponding secondary amines from their aldehyde and aniline precursors.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Chemistry
Publisher:	Wiley
ISSN:	1615-4150
Funders:	The Royal Society
Date of First Compliant Deposit:	11 May 2017
Date of Acceptance:	5 May 2017
Last Modified:	19 Nov 2024 15:30
URI:	https://orca.cardiff.ac.uk/id/eprint/100508

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