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Novel process windows: reactions using tricky reagents

Hutchings, Matthew 2016. Novel process windows: reactions using tricky reagents. PhD Thesis, Cardiff University.
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Flow chemistry has been increasingly used in the last decade as an alternative method to batch chemistry. This methodology allows for conditions that would be unattainable under batch techniques due to the high temperature control, selectivity and safety that flow chemistry allows. The diazidation of styrenes has been investigated under continuous flow conditions, where the inherent safety of flow chemistry allows the use of azides without the concerns usually associated with these reagents. Secondly, the nitroaldol reaction has been transferred to flow conditions. This highlights the safety of continuous flow procedures, as the use of a highly energetic reagent such as nitromethane is easily possible. The Koch-Haaf carbonylation reaction was investigated to demonstrate the use of gases in flow chemistry and the safe handling of toxic gases such as carbon monoxide. Finally the Ritter reaction was used to further demonstrate the suitability of flow chemistry for highly exothermic reactions using concentrated acids; where the temperature control allows for high selectivities.

Item Type: Thesis (PhD)
Status: Unpublished
Schools: Chemistry
Subjects: Q Science > QD Chemistry
Date of First Compliant Deposit: 26 May 2017
Last Modified: 04 Jun 2017 09:51

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