Anatomy of the eye and the role of ocular mucosa in drug delivery

Morrison, Peter W. J. ORCID: https://orcid.org/0000-0002-3712-7908 and Khutoryanskiy, Vitaliy V. 2014. Anatomy of the eye and the role of ocular mucosa in drug delivery. Khutoryanskiy, Vitaly V., ed. Mucoadhesive Materials and Drug Delivery Systems, Wiley Blackwell, (10.1002/9781118794203.ch02)

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Abstract

Treating ocular disorders presents many problems for drug delivery. The preferred means for ocular drug delivery is via the topical route, due to ease of access and patient compliance. Ocular mucosa plays an important role in drug delivery and is the focus of this chapter. The chapter lists some of the main individual components of the eye. For ocular drug delivery four main sites can be targeted: pre-ocular tissue, cornea, anterior and posterior chambers, and vitreous cavity. In vitro methods can help to determine drug release rates, dissolution, degradation, cytotoxicity and membrane permeability. In vivo models using animals allow scientists to evaluate a drugs mode of action in live tissue and to assess any response to the application of that drug. Recent advances in ocular drug delivery have established methods to improve ophthalmic drug retention and enhance corneal permeation as well as development of controlled and sustained release systems.

Item Type:	Book Section
Date Type:	Publication
Status:	Published
Schools:	Pharmacy
Subjects:	R Medicine > RE Ophthalmology R Medicine > RM Therapeutics. Pharmacology
Publisher:	Wiley Blackwell
Last Modified:	21 Oct 2022 07:53
URI:	https://orca.cardiff.ac.uk/id/eprint/100970

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