Advances in ophthalmic drug delivery

Morrison, Peter W. J. ORCID: https://orcid.org/0000-0002-3712-7908 and Khutoryanskiy, Vitaliy V 2014. Advances in ophthalmic drug delivery. Therapeutic Delivery 5 (12) , pp. 1297-1315. 10.4155/tde.14.75

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Abstract

Various strategies for ocular drug delivery are considered; from basic formulation techniques for improving availability of drugs; viscosity enhancers and mucoadhesives aid drug retention and penetration enhancers promote drug transport into the eye. The use of drug-loaded contact lenses and ocular inserts allows drugs to be better placed where they are needed for more direct delivery. Developments in ocular implants gives a means to overcome the physical barriers that traditionally prevented effective treatment. Implant technologies are under development allowing long-term drug delivery from a single procedure, these devices allow posterior chamber diseases to be effectively treated. Future developments could bring artificial corneas to eliminate the need for donor tissue and one-off implantable drug depots lasting the patient's lifetime.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Pharmacy
Subjects:	R Medicine > RE Ophthalmology R Medicine > RM Therapeutics. Pharmacology
Publisher:	Future Science
ISSN:	2041-5990
Date of First Compliant Deposit:	30 May 2017
Date of Acceptance:	8 December 2014
Last Modified:	18 Nov 2024 02:15
URI:	https://orca.cardiff.ac.uk/id/eprint/100972

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