Covelli, D. and Ludgate, Marian Elizabeth 2017. The thyroid, the eyes and the gut: a possible connection. Journal of Endocrinological Investigation 40 (6) , pp. 567-576. 10.1007/s40618-016-0594-6 |
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Abstract
Graves’ disease (GD) is an autoimmune disorder responsible for 60–90% of thyrotoxicosis, with an incidence of 1 to 2 cases per 1000 population per year in England. Graves’ orbitopathy (GO) is the most frequent extrathyroidal manifestation, not provoked directly by abnormal thyroid hormone levels, but by the consequence of the underlying autoimmune process. The aetiology of autoimmune disorders is due to an interplay between susceptibility genes and environmental factors, such as infections and stress. What triggers the autoimmune reaction to a specific site of the body is not yet clearly understood. The lack of knowledge in GD and GO pathogenesis implicates therapies that only limit damage but do not prevent disease onset.
Item Type: | Article |
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Date Type: | Publication |
Status: | Published |
Schools: | Medicine |
Subjects: | R Medicine > R Medicine (General) |
Publisher: | Springer |
ISSN: | 1720-8386 |
Funders: | EU FP7 |
Date of First Compliant Deposit: | 5 September 2017 |
Date of Acceptance: | 5 December 2016 |
Last Modified: | 02 Dec 2024 16:15 |
URI: | https://orca.cardiff.ac.uk/id/eprint/101154 |
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