Ruffino, J. S., Davies, N. A., Morris, K., Ludgate, Marian, Zhang, Lei ORCID: https://orcid.org/0000-0003-3536-8692, Webb, R. and Thomas, A. W. 2016. Moderate-intensity exercise alters markers of alternative activation in circulating monocytes in females: a putative role for PPARγ. European Journal of Applied Physiology 116 (9) , pp. 1671-1682. 10.1007/s00421-016-3414-y |
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Abstract
Monocytes may be primed towards differentiation into classically activated M1 macrophages or alternatively activated M2 macrophages. M1 macrophages greatly contribute to the inflammation which promotes insulin resistance, whereas M2 macrophages resolve inflammation. We have previously shown that exercise increases M2 marker expression in mixed mononuclear cells, possibly via activation of the nuclear transcription factor PPARγ. However, these effects have not been demonstrated specifically within monocytes. Thus, we aimed to investigate whether moderate-intensity exercise elicited similar effects on monocytic M1/M2 marker expression and PPARγ activity to those reported previously in mononuclear cells, so as to further elucidate the mechanisms by which exercise may alter inflammatory status and, accordingly, prevent insulin resistance.
Item Type: | Article |
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Date Type: | Publication |
Status: | Published |
Schools: | Medicine |
Publisher: | Springer |
ISSN: | 1439-6319 |
Funders: | National Institute for Social Care and Health Research |
Date of First Compliant Deposit: | 27 June 2017 |
Date of Acceptance: | 6 June 2016 |
Last Modified: | 04 May 2023 22:26 |
URI: | https://orca.cardiff.ac.uk/id/eprint/101764 |
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