SREBP-1c mediates the retinoid-dependent increase in fatty acid synthase promoter activity in HepG2

Roder, Karim, Zhang, Lei ORCID: https://orcid.org/0000-0003-3536-8692 and Schweizer, Michael 2007. SREBP-1c mediates the retinoid-dependent increase in fatty acid synthase promoter activity in HepG2. FEBS Letters 581 (14) , pp. 2715-2720. 10.1016/j.febslet.2007.05.022

Full text not available from this repository.

Abstract

Treatment of HepG2 with all-trans retinoic acid (RA) induces expression of fatty acid synthase (FAS) mRNA and protein. Transfections show that the FAS promoter positively responds to retinoid X receptor (RXR) but not to RA receptor (RAR) agonists. Since RXR alone is capable of mediating the RA response of FAS, the existence of a classical RA-responsive element in the FAS promoter may be ruled out. Binding sites for NF-Y and SREBP-1 proved to be essential for the RA response. Exposure to all-trans RA increased mRNA and protein levels of SREBP-1, a transcriptional activator for FAS. Overexpression of a dominant-negative form of SREBP-1c diminished the RA-dependent increase in promoter activity. These data demonstrate that RXR ligands can stimulate the expression of a lipogenic gene solely by inducing transcription and cleavage of membrane-bound SREBP-1c.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Medicine
Publisher:	Elsevier
ISSN:	0014-5793
Date of First Compliant Deposit:	27 June 2017
Last Modified:	02 Nov 2022 11:22
URI:	https://orca.cardiff.ac.uk/id/eprint/101770

Citation Data

Cited 40 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item