Zabkiewicz, Catherine, Resaul, Jeyna, Hargest, Rachel  ORCID: https://orcid.org/0000-0001-9830-3832, Jiang, Wen Guo ORCID: https://orcid.org/0000-0002-3283-1111 and Ye, Lin ORCID: https://orcid.org/0000-0002-0303-2409
2017.
Increased expression of follistatin in breast cancer reduces invasiveness and clinically correlates with better survival.
Cancer Genomics and Proteomics
14
(4)
, pp. 241-251.
10.21873/cgp.20035
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Abstract
Background/Aim: Activin and its antagonist follistatin (FST) have been implicated in several solid tumours. This study investigated the role of FST in breast cancer. Materials and Methods: FST expression was examined using reverse transcription polymerase chain reaction (RT-PCR), real-time quantitative polymerase chain reaction (qPCR) and immunohistochemistry in a cohort of breast cancer samples. Expression was correlated to pathological and prognostic parameters in our patient cohort. FST was overexpressed in MCF-7 cells and assays for growth and invasion were performed. Results: FST is expressed in breast tissue, in the cytoplasm of mammary epithelial cells. Expression was decreased in breast cancer tissue in comparison to normal mammary tissue. Over-expression of FST in vitro led to significantly increased growth rate and reduced invasion. Higher FST associates with lower-grade tumours and better survival. Conclusion: Our results suggest a role for FST as a suppressor of invasion and metastasis in breast cancer.
| Item Type: | Article |
|---|---|
| Date Type: | Publication |
| Status: | Published |
| Schools: | Schools > Medicine |
| Subjects: | R Medicine > R Medicine (General) |
| Publisher: | International Institute of Anticancer Research (IIAR) |
| ISSN: | 1109-6535 |
| Date of First Compliant Deposit: | 29 June 2017 |
| Date of Acceptance: | 31 May 2017 |
| Last Modified: | 18 Aug 2023 11:57 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/101923 |
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