Increased expression of follistatin in breast cancer reduces invasiveness and clinically correlates with better survival

Zabkiewicz, Catherine, Resaul, Jeyna, Hargest, Rachel ORCID: https://orcid.org/0000-0001-9830-3832, Jiang, Wen Guo ORCID: https://orcid.org/0000-0002-3283-1111 and Ye, Lin ORCID: https://orcid.org/0000-0002-0303-2409 2017. Increased expression of follistatin in breast cancer reduces invasiveness and clinically correlates with better survival. Cancer Genomics and Proteomics 14 (4) , pp. 241-251. 10.21873/cgp.20035

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Abstract

Background/Aim: Activin and its antagonist follistatin (FST) have been implicated in several solid tumours. This study investigated the role of FST in breast cancer. Materials and Methods: FST expression was examined using reverse transcription polymerase chain reaction (RT-PCR), real-time quantitative polymerase chain reaction (qPCR) and immunohistochemistry in a cohort of breast cancer samples. Expression was correlated to pathological and prognostic parameters in our patient cohort. FST was overexpressed in MCF-7 cells and assays for growth and invasion were performed. Results: FST is expressed in breast tissue, in the cytoplasm of mammary epithelial cells. Expression was decreased in breast cancer tissue in comparison to normal mammary tissue. Over-expression of FST in vitro led to significantly increased growth rate and reduced invasion. Higher FST associates with lower-grade tumours and better survival. Conclusion: Our results suggest a role for FST as a suppressor of invasion and metastasis in breast cancer.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > R Medicine (General)
Publisher:	International Institute of Anticancer Research (IIAR)
ISSN:	1109-6535
Date of First Compliant Deposit:	29 June 2017
Date of Acceptance:	31 May 2017
Last Modified:	18 Aug 2023 11:57
URI:	https://orca.cardiff.ac.uk/id/eprint/101923

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