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Effect of early-term birth on respiratory symptoms and lung function in childhood and adolescence

Kotecha, Sarah, Watkins, William John ORCID:, Lowe, John ORCID:, Henderson, A. John and Kotecha, Sailesh ORCID: 2016. Effect of early-term birth on respiratory symptoms and lung function in childhood and adolescence. Pediatric Pulmonology 51 (11) , pp. 1212-1221. 10.1002/ppul.23448

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Background Early-term-born subjects, (37–38 weeks’ gestation), form a large part of the population and have an increased risk of neonatal respiratory morbidity and childhood respiratory symptoms; there is a paucity of data on their later lung function. We sought to (1) compare lung function at 8–9 and 14–17 years in early-term-born children with full-term-born children (39–43 weeks’ gestation); (2) assess the role of caesarean section delivery; and (3) compare respiratory symptoms and diagnosis of asthma. Methods Caucasian, singleton, term births from the Avon Longitudinal Study of Parents and Children (n = 14,062) who had lung spirometry at 8–9 (n = 5,465) and/or 14–17 (n = 3,666) years were classified as early or full term. Results At 8–9 years, standardized spirometry measures, although within the normal range, were lower in the early-term-born group, (n = 911), compared to full-term controls (n = 4,554). Delivery by caesarean section did not influence later spirometry, and the effect of early-term birth was not modified by delivery by caesarean section. At 14–17 years, the spirometry measures in the early-term group, (n = 602), were similar to the full-term group (3,064), and the rates of asthma and respiratory symptoms were also similar between the two gestation groups. Conclusions Early-term-born children had lower lung function values at 8–9 years compared to the full-term group, but were similar by 14–17 years of age. Delivery at early term should be avoided due to early and late morbidity.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
Publisher: Wiley-Blackwell
ISSN: 8755-6863
Date of Acceptance: 8 April 2016
Last Modified: 15 Apr 2023 01:16

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