Nanoporous aluminosilicate catalyzed Friedel-Crafts alkylation reactions of indoles with aldehydes and acetals

Kubczyk, T. M., Williams, S. M., Kean, J. R., Davies, Thomas Edward, Taylor, Stuart H. ORCID: https://orcid.org/0000-0002-1933-4874 and Graham, Andrew E. 2011. Nanoporous aluminosilicate catalyzed Friedel-Crafts alkylation reactions of indoles with aldehydes and acetals. Green Chemistry 13 (9) , pp. 2320-2325. 10.1039/c1gc15669a

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Abstract

Nanoporous aluminosilicate materials efficiently catalyze Friedel-Crafts reactions of indoles to produce bisindolylalkane products. These reactions proceed rapidly and in high yields when acetals are used in place of the more commonly used carbonyl reagents. It is possible to capitalise on the large difference in the rates of reaction observed with aldehydes and acetals to develop a tandem acetalization-Friedel-Crafts protocol in which the acetal is generated in situ and undergoes subsequent reaction. © 2011 The Royal Society of Chemistry.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Cardiff Catalysis Institute (CCI) Chemistry
Subjects:	Q Science > QD Chemistry
Publisher:	Royal Society of Chemistry
ISSN:	1463-9262
Last Modified:	14 Nov 2024 08:40
URI:	https://orca.cardiff.ac.uk/id/eprint/10217

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