On the binding modes of metal NHC complexes with DNA secondary structures: implications for therapy and imaging

Karaca, Özden, Meier-Menches, Samuel, Casini, Angela ORCID: https://orcid.org/0000-0003-1599-9542 and Kühn, Fritz E. 2017. On the binding modes of metal NHC complexes with DNA secondary structures: implications for therapy and imaging. Chemical Communications 59 , pp. 8249-8260. 10.1039/C7CC03074F

Preview

PDF - Accepted Post-Print Version Download (1MB) | Preview

Abstract

Organometallic compounds currently occupy an important place in the field of medicinal inorganic chemistry due to the unique chemical properties of metal coordination compounds. Particularly, metal compounds ligated by N-heterocyclic carbenes (NHC) have shown high potential for biomedical applications as antimicrobial and anticancer agents during the recent 15 years. Although further studies are necessary to validate the modes of action of this family of compounds, a number of biological targets have been identified, including DNA secondary structures. This perspective review aims at providing an overview of the most representative examples of metal NHC complexes reacting with nucleic acids via different binding modes. It is organized according to the type of DNA secondary structure targeted by metal NHCs, highlighting the possible advantages of biomedical applications, including therapy and imaging.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Chemistry
Subjects:	Q Science > QD Chemistry
Publisher:	RSC Publishing
ISSN:	1359-7345
Date of First Compliant Deposit:	18 July 2017
Date of Acceptance:	19 June 2017
Last Modified:	04 May 2023 17:54
URI:	https://orca.cardiff.ac.uk/id/eprint/102523

Citation Data

Cited 59 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item