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A new graft insertion device for descemet stripping automated endothelial keratoplasty

Soma, T., Koh, S., Maeda, N., Mitomo, K., Quantock, Andrew J. ORCID: and Nishida, K. 2017. A new graft insertion device for descemet stripping automated endothelial keratoplasty. Cornea 36 (11) , pp. 1432-1436. 10.1097/ICO.0000000000001302

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Purpose: Corneal endothelial dysfunction is a major indicator for corneal graft surgery worldwide, and whilst surgical intervention via a range of posterior lamellar surgeries has proven to be hugely beneficial, challenges remain. This is especially so where the anterior chamber is relatively shallow, as is often the case in the Asian population, though not exclusively so. Here, we introduce a new insertion device to deliver endothelial graft tissue for Descemet stripping automated endothelial keratoplasty (DSAEK). Methods: A new surgical tool was designed and manufactured so as to enable a one-step insertion of corneal graft tissue into the anterior chamber based on a pressure-flow concept, rather than the a pull-through one. This was tested ex vivo to assess endothelial cell damage, then performed in 12 first-in-man surgeries. Results: Pre-cut DSAEK lenticules implanted in donor corneas ex vivo via the new technique showed less endothelial cell damage occurs compared to a pull-through technique. Grafts were successful in all patients receiving the new surgery, with no cases of primary graft failure. Conclusion: The newly developed DSAEK inserter is a simple and useful tool for endothelial graft delivery, lessening intraoperative mechanical stress on the graft tissue.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Optometry and Vision Sciences
Subjects: R Medicine > RE Ophthalmology
Uncontrolled Keywords: cornea, corneal endothelium, endothelial keratoplasty, DSAEK
Publisher: Lippincott, Williams & Wilkins
ISSN: 0277-3740
Date of First Compliant Deposit: 20 July 2017
Date of Acceptance: 14 June 2017
Last Modified: 06 Nov 2023 22:48

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