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Dendritic cell lineage potential in human early hematopoietic progenitors

Helft, Julie, Anjos-Afonso, Fernando, van der Veen, Annemarthe G., Chakravarty, Probir, Bonnet, Dominique and Reis e Sousa, Caetano 2017. Dendritic cell lineage potential in human early hematopoietic progenitors. Cell Reports 20 (3) , pp. 529-537. 10.1016/j.celrep.2017.06.075

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Conventional dendritic cells (cDCs) are thought to descend from a DC precursor downstream of the common myeloid progenitor (CMP). However, a mouse lymphoid-primed multipotent progenitor has been shown to generate cDCs following a DCspecific developmental pathway independent of monocyte and granulocyte poiesis. Similarly, here we show that, in humans, a large fraction of multipotent lymphoid early progenitors (MLPs) gives rise to cDCs, in particular the subset known as cDC1, identified by co-expression of DNGR-1 (CLEC9A) and CD141 (BDCA-3). Single-cell analysis indicates that over one-third of MLPs have the potential to efficiently generate cDCs. cDC1s generated from CMPs or MLPs do not exhibit differences in transcriptome or phenotype. These results demonstrate an early imprinting of the cDC lineage in human hematopoiesis and highlight the plasticity of developmental pathways giving rise to human DCs.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Additional Information: This is an open access article under the terms of the CC-BY license.
Publisher: Elsevier
ISSN: 2211-1247
Date of First Compliant Deposit: 2 August 2017
Date of Acceptance: 23 June 2017
Last Modified: 07 Jan 2021 15:12

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