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Defining key concepts of intestinal and epithelial cancer biology through the use of mouse models

Phesse, Toby ORCID:, Marsh Durban, Victoria and Sansom, Owen J. 2017. Defining key concepts of intestinal and epithelial cancer biology through the use of mouse models. Carcinogenesis 38 (10) , pp. 953-965. 10.1093/carcin/bgx080

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Over the past 20 years, huge advances have been made in modelling human diseases such as cancer using genetically modified mice. Accurate in vivo models are essential to examine the complex interaction between cancer cells, surrounding stromal cells, tumour-associated inflammatory cells, fibroblast and blood vessels, and to recapitulate all the steps involved in metastasis. Elucidating these interactions in vitro has inherent limitations, and thus animal models are a powerful tool to enable researchers to gain insight into the complex interactions between signalling pathways and different cells types. This review will focus on how advances in in vivo models have shed light on many aspects of cancer biology including the identification of oncogenes, tumour suppressors and stem cells, epigenetics, cell death and context dependent cell signalling.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
European Cancer Stem Cell Research Institute (ECSCRI)
Publisher: Oxford University Press
ISSN: 0147-4006
Date of First Compliant Deposit: 4 August 2017
Date of Acceptance: 1 August 2017
Last Modified: 07 Nov 2023 08:31

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