Transcriptional profiling of sonic hedgehog in a prospective cohort of breast cancer in a Pakistani population

Kiran Riaz, Syeda, Ye, Lin ORCID: https://orcid.org/0000-0002-0303-2409, Sahar, Namood E., Aman, D., Qadir, J., Sarwar Khan, J., Saeed, M., Jiang, Wen Guo ORCID: https://orcid.org/0000-0002-3283-1111 and Faraz Arshad Malik, M. 2017. Transcriptional profiling of sonic hedgehog in a prospective cohort of breast cancer in a Pakistani population. Anticancer Research 37 (8) , pp. 4449-4454. 10.21873/anticanres.11840

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Abstract

Background/Aim: Constitutive activation of Sonic hedgehog (SHH) has been observed in different types of cancers. In the present study, expressional profiling of SHH in a breast cancer cohort (n=150) of a Pakistani population and its association with different molecular subtypes have been explored. Materials and Methods: qRT-PCR and IHC were performed for expression analysis of SHH and its association with ER, PR, HER2 and Ki-67 were also statistically analyzed. Results: A significant over-expression of SHH was observed in tumor tissues in comparison to their respective controls (p<0.0001). A strong positive correlation was seen between SHH and proliferation marker (r=0.635, p=0). SHH expression was significantly high among patients with advanced tumor grade, stage, nodal involvement and metastasis. Furthermore, both luminal-B and triple-negative subtypes of cohort showed increased expression of SHH. Conclusion: Based on these findings, SHH may be used as a potential biomarker for breast carcinogenesis.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Publisher:	International Institute of Anticancer Research
ISSN:	0250-7005
Funders:	National Research Program for University of the Higher Education Commission of Pakistan and Cardiff University
Date of First Compliant Deposit:	11 August 2017
Date of Acceptance:	13 June 2017
Last Modified:	05 May 2023 15:23
URI:	https://orca.cardiff.ac.uk/id/eprint/103537

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