Kalbassi, Shireene, Bachmann, Sven O.  ORCID: https://orcid.org/0000-0002-7917-5799, Cross, Ellen, Roberton, Victoria H. and Baudouin, Stephane J. ORCID: https://orcid.org/0000-0001-6902-6071
2017.
Male and female mice lacking Neuroligin-3 modify the behavior of their wild-type littermates.
eNeuro
4
(4)
, ENEURO.0145-17.2017.
10.1523/ENEURO.0145-17.2017
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Abstract
In most mammals, including humans, the postnatal acquisition of normal social and nonsocial behavior criticallydepends on interactions with peers. Here we explore the possibility that mixed-group housing of mice carrying adeletion of Nlgn3, a gene associated with autism spectrum disorders, and their wild-type littermates induceschanges in each other’s behavior. We have found that, when raised together, male Nlgn3 knockout mice and theirwild-type littermates displayed deficits in sociability. Moreover, social submission in adult male Nlgn3 knockoutmice correlated with an increase in their anxiety. Re-expression of Nlgn3 in parvalbumin-expressing cells intransgenic animals rescued their social behavior and alleviated the phenotype of their wild-type littermates, furtherindicating that the social behavior of Nlgn3 knockout mice has a direct and measurable impact on wild-typeanimals’ behavior. Finally, we showed that, unlike male mice, female mice lacking Nlgn3 were insensitive to theirpeers’ behavior but modified the social behavior of their littermates. Altogether, our findings show that theenvironment is a critical factor in the development of behavioral phenotypes in transgenic and wild-type mice. Inaddition, these results reveal that the social environment has a sexually dimorphic effect on the behavior of micelacking Nlgn3, being more influential in males than females.
| Item Type: | Article |
|---|---|
| Date Type: | Publication |
| Status: | Published |
| Schools: | Schools > Biosciences |
| Additional Information: | This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license. |
| Publisher: | Society for Neuroscience: eNeuro |
| ISSN: | 2373-2822 |
| Funders: | Wellcome Trust |
| Related URLs: | |
| Date of First Compliant Deposit: | 16 August 2017 |
| Date of Acceptance: | 9 July 2017 |
| Last Modified: | 13 Dec 2024 10:55 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/103664 |
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