Autoantibodies of IgM and IgG classes show differences in recognition of multiple autoantigens in chronic obstructive pulmonary disease

Shindi, Reham, Almehairi, Amna, Negm, Ola H., Kalsheker, Noor, Gale, Nichola ORCID: https://orcid.org/0000-0001-5207-9863, Shale, Dennis J., Harrison, Timothy W., Bolton, Charlotte E., John, Michelle, Todd, Ian, Tighe, Patrick J. and Fairclough, Lucy C. 2017. Autoantibodies of IgM and IgG classes show differences in recognition of multiple autoantigens in chronic obstructive pulmonary disease. Clinical Immunology 183 , pp. 344-353. 10.1016/j.clim.2017.09.020

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Abstract

Autoimmunity occurs in chronic obstructive pulmonary disease (COPD). We describe an antigen microarray for detecting serum autoantibodies (AAbs) to determine how IgM, as well as IgG, AAbs distinguish patients with COPD from controls with a history of smoking without COPD. All COPD patients' sera contained elevated levels of AAbs to some of 30 autoantigens. There were significant differences in the autoantigenic specificities of IgM AAbs compared to IgG AAbs in the COPD sera: for example, AAbs to histone and scl-70 were mainly IgG, whereas AAbs to CENP-B and La/ssB were mainly IgM; by contrast, IgM and IgG AAbs to collagen-V were equally prevalent. Thus, a combination of IgM and IgG AAbs specific for multiple autoantigens are detected in all cases of COPD at a level at which all non-COPD controls are negative for AAbs. This highlights the importance of different classes of AAbs to a range of autoantigens in COPD.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Healthcare Sciences
Publisher:	Elsevier
ISSN:	1521-6616
Date of First Compliant Deposit:	28 September 2017
Date of Acceptance:	22 September 2017
Last Modified:	22 Nov 2024 22:45
URI:	https://orca.cardiff.ac.uk/id/eprint/105019

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