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Developmental coordination disorder, psychopathology and IQ in 22q11.2 deletion syndrome

Cunningham, Adam C., Delport, Sue ORCID:, Cumines, Wendy, Busse, Monica, Linden, David E. J. ORCID:, Hall, Jeremy ORCID:, Owen, Michael J. ORCID: and van den Bree, Marianne ORCID: 2018. Developmental coordination disorder, psychopathology and IQ in 22q11.2 deletion syndrome. British Journal of Psychiatry 212 (1) , pp. 27-33. 10.1192/bjp.2017.6

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Background 22q11.2 Deletion Syndrome (22q11.2DS) is associated with high rates of neurodevelopmental disorder, however the links between developmental coordination disorder, intellectual function and psychiatric disorder remain unexplored. Aims Establish the prevalence of indicative Developmental Coordination Disorder (DCD) in children with 22q11.2DS, and examine associations with IQ, neuro-cognition and psychopathology. In-home neuro-cognitive assessments and psychiatric interviews of 70 children with 22q11.2DS (mean age=11.24, s.d=2.2) and 32 control siblings (mean age=11.5, s.d=2.1). Nine children with 22q11.2DS and indicative DCD were subsequently assessed in an occupational therapy clinic. Results Indicative DCD was found in 81.4% of children with 22q11.2DS, compared to 6.3% in control siblings (OR=36.7, p<0.001). Eight of nine (89%) children with indicative DCD met DSM-5 criteria for DCD. Poorer coordination was associated with increased numbers of anxiety, (p<0.001), Attention Deficit Hyperactivity Disorder (ADHD) (p<0.001) and Autism Spectrum Disorder (ASD) symptoms (p<0.001) in children with 22q11.2DS. Furthermore, 100% of children with 22q11.2DS and ADHD had indicative DCD, as did 90% of children with anxiety disorder and 96% of children who screened positive for ASD. DCDQ score was related to sustained attention (p=0.006), even after history of epileptic fits (p=0.006) and heart problems (p=0.009) was taken into account.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Cardiff University Brain Research Imaging Centre (CUBRIC)
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Neuroscience and Mental Health Research Institute (NMHRI)
Additional Information: This is an author-produced electronic version of an article accepted for publication in the British Journal of Psychiatry. The definitive publisher-authenticated version is available online at
Publisher: Cambridge University Press
ISSN: 0007-1250
Funders: Medical Research Council
Date of First Compliant Deposit: 5 October 2017
Date of Acceptance: 22 September 2017
Last Modified: 05 Jun 2024 01:08

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