An easy-to-machine electrochemical flow microreactor: efficient synthesis of isoindolinone and flow functionalization

Folgueiras-Amador, Ana A., Philipps, Kai, Guilbaud, Sebastien, Poelakker, Jarno and Wirth, Thomas ORCID: https://orcid.org/0000-0002-8990-0667 2017. An easy-to-machine electrochemical flow microreactor: efficient synthesis of isoindolinone and flow functionalization. Angewandte Chemie International Edition 56 (48) , pp. 15446-15450. 10.1002/anie.201709717

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Abstract

Flow electrochemistry is an efficient methodology to generate radical intermediates. An electrochemical flow microreactor has been designed and manufactured to improve the efficiency of electrochemical flow reactions. With this device only little or no supporting electrolytes are needed, making processes less costly and enabling easier purification. This is demonstrated by the facile synthesis of amidyl radicals used in intramolecular hydroaminations to produce isoindolinones. The combination with inline mass spectrometry facilitates a much easier combination of chemical steps in a single flow process

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Chemistry
Subjects:	Q Science > QD Chemistry
Publisher:	Wiley
ISSN:	1433-7851
Date of First Compliant Deposit:	24 October 2017
Date of Acceptance:	11 October 2017
Last Modified:	05 May 2023 18:53
URI:	https://orca.cardiff.ac.uk/id/eprint/105848

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