Characterization of hydrophilic gold(I) N-Heterocyclic Carbene (NHC) complexes as potent TrxR inhibitors using biochemical and mass spectrometric approaches

Karaca, Özden, Scalcon, Valeria, Meier-Menches, Samuel M., Bonsignore, Riccardo ORCID: https://orcid.org/0000-0003-2699-4384, Brouwer, Jurriaan M. J. L., Tonolo, Federica, Folda, Alessandra, Rigobello, Maria Pia, Kühn, Fritz E. and Casini, Angela ORCID: https://orcid.org/0000-0003-1599-9542 2017. Characterization of hydrophilic gold(I) N-Heterocyclic Carbene (NHC) complexes as potent TrxR inhibitors using biochemical and mass spectrometric approaches. Inorganic Chemistry 10.1021/acs.inorgchem.7b02345

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Abstract

The synthesis of novel hydrophilic gold(I) NHC complexes is reported. Selected compounds distinctly target the pivotal biological target thioredoxin reductase (TrxR) in the nanomolar range, as for the benchmark anticancer drug auranofin, and exhibit remarkable antiproliferative effects against human ovarian cancer cells.

Item Type:	Article
Date Type:	Published Online
Status:	Published
Schools:	Schools > Chemistry
Publisher:	American Chemical Society
ISSN:	0020-1669
Date of First Compliant Deposit:	14 November 2017
Date of Acceptance:	2 November 2017
Last Modified:	19 Nov 2024 21:45
URI:	https://orca.cardiff.ac.uk/id/eprint/106490

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