Karaca, Özden, Scalcon, Valeria, Meier-Menches, Samuel M., Bonsignore, Riccardo ORCID: https://orcid.org/0000-0003-2699-4384, Brouwer, Jurriaan M. J. L., Tonolo, Federica, Folda, Alessandra, Rigobello, Maria Pia, Kühn, Fritz E. and Casini, Angela ORCID: https://orcid.org/0000-0003-1599-9542 2017. Characterization of hydrophilic gold(I) N-Heterocyclic Carbene (NHC) complexes as potent TrxR inhibitors using biochemical and mass spectrometric approaches. Inorganic Chemistry 10.1021/acs.inorgchem.7b02345 |
Preview |
PDF
- Accepted Post-Print Version
Download (1MB) | Preview |
Official URL: http://dx.doi.org/10.1021/acs.inorgchem.7b02345
Abstract
The synthesis of novel hydrophilic gold(I) NHC complexes is reported. Selected compounds distinctly target the pivotal biological target thioredoxin reductase (TrxR) in the nanomolar range, as for the benchmark anticancer drug auranofin, and exhibit remarkable antiproliferative effects against human ovarian cancer cells.
Item Type: | Article |
---|---|
Date Type: | Published Online |
Status: | Published |
Schools: | Chemistry |
Publisher: | American Chemical Society |
ISSN: | 0020-1669 |
Date of First Compliant Deposit: | 14 November 2017 |
Date of Acceptance: | 2 November 2017 |
Last Modified: | 10 Nov 2023 06:54 |
URI: | https://orca.cardiff.ac.uk/id/eprint/106490 |
Citation Data
Cited 55 times in Scopus. View in Scopus. Powered By Scopus® Data
Actions (repository staff only)
Edit Item |