Current treatments to counter sleep dysfunction as a pathogenic stimulus of fibromyalgia

Choy, Ernest H. ORCID: https://orcid.org/0000-0003-4459-8609 2016. Current treatments to counter sleep dysfunction as a pathogenic stimulus of fibromyalgia. Pain Management 6 (4) , p. 339. 10.2217/pmt-2016-0009

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Abstract

Fibromyalgia is characterized by chronic widespread pain, fatigue and nonrestorative sleep. Polysomnography showed reduced short-wave sleep and abnormal alpha rhythms during nonrapid eye movement sleep in patients with fibromyalgia. However, sleep dysfunction might be pathogenic in fibromyalgia since myalgia and fatigue could be induced in healthy individuals by disrupting sleep. Poor sleep quality was a major risk factor for the subsequent development of chronic widespread pain in healthy pain-free individuals. Sleep disruption leads to impairment of the descending pain inhibition pathways. Aside from good sleep, hygiene, exercise can promote sleep. Among currently available pharmacological treatments, evidence suggests amitriptyline and pregabalin can improve sleep in fibromyalgia.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Publisher:	Future Medicine
ISSN:	1758-1869
Date of First Compliant Deposit:	16 March 2018
Last Modified:	06 Nov 2023 18:56
URI:	https://orca.cardiff.ac.uk/id/eprint/106528

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