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Co-stimulation: novel methods for preventing viral-induced lung inflammation

Hussell, T, Snelgrove, R, Humphreys, Ian ORCID: and Williams, A. E 2004. Co-stimulation: novel methods for preventing viral-induced lung inflammation. Trends in Molecular Medicine 10 (8) , pp. 379-386. 10.1016/j.molmed.2004.06.006

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Respiratory infections cause significant morbidity and mortality worldwide. Although an immune response is required to eliminate respiratory pathogens, if unchecked, it can damage surrounding tissues and block primary lung function. Based on our knowledge of immune T-cell activation, there are several pathways to which immune intervention could be applied. However, relatively few interventions target only those immune cells that are responding to antigens. OX40 and 4-1BB are members of the tumour necrosis factor receptor family and are expressed on the surface of T cells in several inflammatory conditions

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
Publisher: Elsevier
ISSN: 1471-4914
Date of Acceptance: 1 August 2004
Last Modified: 03 Nov 2022 10:10

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