Prospective, multicentre study of external ventricular drainage-related infections in the UK and Ireland

Jamjoom, Aimun A B, Joannides, Alexis J, Poon, Michael Tin-Chung, Chari, Aswin, Zaben, Malik ORCID: https://orcid.org/0000-0002-7446-4532, Abdulla, Mutwakil A H, Roach, Joy, Glancz, Laurence J, Solth, Anna, Duddy, John, Brennan, Paul M, Bayston, Roger, Bulters, Diederik O, Mallucci, Conor L, Jenkinson, Michael D, Gray, William ORCID: https://orcid.org/0000-0001-7595-8887, Kandasamy, Jothy, Hutchinson, Peter J, Kolias, Angelos G and Ahmed, Aminul I 2017. Prospective, multicentre study of external ventricular drainage-related infections in the UK and Ireland. Journal of Neurology, Neurosurgery & Psychiatry 10.1136/jnnp-2017-316415

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Abstract

Objectives External ventricular drain (EVD) insertion is a common neurosurgical procedure. EVD-related infection (ERI) is a major complication that can lead to morbidity and mortality. In this study, we aimed to establish a national ERI rate in the UK and Ireland and determine key factors influencing the infection risk. Methods A prospective multicentre cohort study of EVD insertions in 21 neurosurgical units was performed over 6 months. The primary outcome measure was 30-day ERI. A Cox regression model was used for multivariate analysis to calculate HR. Results A total of 495 EVD catheters were inserted into 452 patients with EVDs remaining in situ for 4700 days (median 8 days; IQR 4–13). Of the catheters inserted, 188 (38%) were antibiotic-impregnated, 161 (32.5%) were plain and 146 (29.5%) were silver-bearing. A total of 46 ERIs occurred giving an infection risk of 9.3%. Cox regression analysis demonstrated that factors independently associated with increased infection risk included duration of EVD placement for ≥8 days (HR=2.47 (1.12–5.45); p=0.03), regular sampling (daily sampling (HR=4.73 (1.28–17.42), p=0.02) and alternate day sampling (HR=5.28 (2.25–12.38); p<0.01). There was no association between catheter type or tunnelling distance and ERI. Conclusions In the UK and Ireland, the ERI rate was 9.3% during the study period. The study demonstrated that EVDs left in situ for ≥8 days and those sampled more frequently were associated with a higher risk of infection. Importantly, the study showed no significant difference in ERI risk between different catheter types.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Medicine Neuroscience and Mental Health Research Institute (NMHRI)
Publisher:	BMJ Publishing Group
ISSN:	0022-3050
Date of First Compliant Deposit:	7 December 2017
Date of Acceptance:	9 October 2017
Last Modified:	14 Sep 2024 01:28
URI:	https://orca.cardiff.ac.uk/id/eprint/107411

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