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Age-related delay in visual and auditory evoked responses is mediated by white- and grey-matter differences

Price, D., Tyler, L. K., Henriques, R. Neto, Campbell, K. L., Williams, N., Treder, M. S.

, Taylor, J. R. and Henson, R. N. A. 2017. Age-related delay in visual and auditory evoked responses is mediated by white- and grey-matter differences. Nature Communications 8 , 15671. 10.1038/ncomms15671

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Official URL: https://doi.org/10.1038/ncomms15671

Abstract

Slowing is a common feature of ageing, yet a direct relationship between neural slowing and brain atrophy is yet to be established in healthy humans. We combine magnetoencephalographic (MEG) measures of neural processing speed with magnetic resonance imaging (MRI) measures of white and grey matter in a large population-derived cohort to investigate the relationship between age-related structural differences and visual evoked field (VEF) and auditory evoked field (AEF) delay across two different tasks. Here we use a novel technique to show that VEFs exhibit a constant delay, whereas AEFs exhibit delay that accumulates over time. White-matter (WM) microstructure in the optic radiation partially mediates visual delay, suggesting increased transmission time, whereas grey matter (GM) in auditory cortex partially mediates auditory delay, suggesting less efficient local processing. Our results demonstrate that age has dissociable effects on neural processing speed, and that these effects relate to different types of brain atrophy.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Computer Science & Informatics Psychology
Additional Information:	Open Access This article is licensed under a Creative Commons Attribution 4.0 International License
Publisher:	Nature Research
ISSN:	2041-1723
Date of First Compliant Deposit:	18 July 2019
Date of Acceptance:	18 April 2017
Last Modified:	06 May 2023 03:44
URI:	https://orca.cardiff.ac.uk/id/eprint/108242