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Delayed and localized pemphigus vulgaris after breast cancer radiotherapy

Tang, Hiu Kwan Carolyn, Lee, Doreen Yin Hui, Thompson, Ian, Ingram, John R. ORCID:, Stone, Natalie and Patel, Girish K. 2017. Delayed and localized pemphigus vulgaris after breast cancer radiotherapy. The Breast Journal 23 (6) , pp. 747-749. 10.1111/tbj.12910

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Breast cancer treatment involving ionizing radiation causes characteristic radiation dermatitis in the majority of patients. The DNA damaging effects of radiation can rarely predispose to primary inflammatory dermatoses, such as pemphigus vulgaris. In such cases, the disease presents with all the hallmarks of the primary dermatosis, but the eruption is limited to the field of irradiation and is often amenable to treatment. In contrast, occurrence of generalized pemphigus vulgaris in this setting may mean cancer recurrence. The mechanism by which radiotherapy induces localized disease remains unknown, but there is likely a loss of self-tolerance which maybe coupled to antigen exposure.

Item Type: Article
Date Type: Published Online
Status: Published
Schools: Biosciences
European Cancer Stem Cell Research Institute (ECSCRI)
Publisher: Wiley
ISSN: 1075-122X
Date of First Compliant Deposit: 24 January 2018
Date of Acceptance: 2 November 2016
Last Modified: 07 Nov 2023 21:21

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