Dynamic reconfiguration of hippocampal interneuron circuits during spatial learning

Dupret, David, O'Neill, Joseph ORCID: https://orcid.org/0000-0003-1886-8476 and Csicsvari, Jozsef 2013. Dynamic reconfiguration of hippocampal interneuron circuits during spatial learning. Neuron -Cambridge Ma- 78 (1) , pp. 166-180. 10.1016/j.neuron.2013.01.033

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Abstract

In the hippocampus, cell assemblies forming mnemonic representations of space are thought to arise as a result of changes in functional connections of pyramidal cells. We have found that CA1 interneuron circuits are also reconfigured during goaloriented spatial learning through modification of inputs from pyramidal cells. As learning progressed, new pyramidal assemblies expressed in theta cycles alternated with previously established ones, and eventually overtook them. The firing patterns of interneurons developed a relationship to new, learningrelated assemblies: some interneurons associated their activity with new pyramidal assemblies while some others dissociated from them. These firing associations were explained by changes in the weight of monosynaptic inputs received by interneurons from new pyramidal assemblies, as these predicted the associational changes. Spatial learning thus engages circuit modifications in the hippocampus that incorporate a redistribution of inhibitory activity that might assist in the segregation of competing pyramidal cell assembly patterns in space and time.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Psychology
Publisher:	Elsevier
ISSN:	0896-6273
Date of First Compliant Deposit:	30 January 2018
Date of Acceptance:	28 January 2013
Last Modified:	11 Oct 2023 21:45
URI:	https://orca.cardiff.ac.uk/id/eprint/108578

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