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Plasma L-arginine levels in a rabbit model of hypercholesterolaemia

Williams, John, Lang, Derek, Warden-Smith, Jeremy and Lewis, Malcolm John 1993. Plasma L-arginine levels in a rabbit model of hypercholesterolaemia. Biochemical Pharmacology 46 (11) , pp. 2097-2099. 10.1016/0006-2952(93)90653-E

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A novel method for the quantitation of L-arginine in plasma samples has been developed, based on the technique of enantiomer labelling coupled to the capillary gas chromatographic separation of amino acids. Using this technique plasma L-arginine levels have been measured in rabbits fed a 1% cholesterol-containing diet and compared with rabbits fed a standard diet. Blood cholesterol levels were significantly elevated in the rabbits fed cholesterol but no significant difference was found in plasma L-arginine levels between the cholesterol-fed and control animals. No D-arginine was found in any of the plasma samples. It is concluded that the impairment in endothelium-dependent relaxation previously described in this animal model of hypercholesterolaemia is not due to deficiency of plasma L-arginine.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > RM Therapeutics. Pharmacology
Publisher: Elsevier
ISSN: 0006-2952
Last Modified: 17 Mar 2021 02:34

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