Definitive chemoradiation in patients with inoperable oesophageal carcinoma

Crosby, Thomas David Lewis, Brewster, A. E., Borley, A., Perschky, L., Kehagioglou, Pinelopi, Court, J. and Maughan, Timothy Stanley 2004. Definitive chemoradiation in patients with inoperable oesophageal carcinoma. British Journal of Cancer 90 (1) , pp. 70-75. 10.1038/sj.bjc.6601461

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Abstract

We performed a retrospective study of 90 consecutive cases with inoperable carcinoma of the oesophagus treated with definitive chemoradiation at a single cancer centre between 1995 and 2002. For the last 4 years, 73 patients have received therapy according to an agreed protocol. This outpatient-based regimen involves four cycles of chemotherapy, cycles 3 and 4 given concurrently with 50 Gy external beam radiotherapy (XRT) delivered in 25 fractions over 5 weeks. Cisplatin 60 mg m-2 day-1 is given every 3 weeks together with continuous infusional 5-fluorouracil 300 mg m-2 day-1, reduced to 225 mg m-2 day-1 during the XRT. In all, 45 (50%) patients suffered one or more WHO grade 3/4 toxicity, grade 3 in 93% cases. Patients received more than 90% of the planned chemoradiation schedule. The median overall survival was 26 (15, >96) months, 51% (41, 64) and 26% (13, 52) surviving 2 and 5 years, respectively. Advanced stage, particularly T4 disease, was associated with a worse prognosis. Patients considered not suitable for surgery for reasons other than their disease, mainly co-morbidity, had a significantly better outcome, median survival 40 (26, >96) months, 2- and 5-year survivals 67% (54, 84) and 32% (13, 79), respectively (P<0.001). This schedule is a feasible, tolerable and effective treatment for patients with oesophageal cancer considered unsuitable for surgery.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > R Medicine (General)
Uncontrolled Keywords:	definitive chemoradiation ; inoperable ; oesophageal cancer
ISSN:	15321827
Last Modified:	03 Aug 2022 01:07
URI:	https://orca.cardiff.ac.uk/id/eprint/109

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