Neurovascular coupling during visual stimulation in Multiple Sclerosis: a MEG-fMRI study

Stickland, Rachael ORCID: https://orcid.org/0000-0003-3398-4272, Allen, Marek, Magazzini, Lorenzo ORCID: https://orcid.org/0000-0002-8934-8374, Singh, Krish D. ORCID: https://orcid.org/0000-0002-3094-2475, Wise, Richard G. ORCID: https://orcid.org/0000-0003-1700-2144 and Tomassini, Valentina ORCID: https://orcid.org/0000-0002-7368-6280 2019. Neurovascular coupling during visual stimulation in Multiple Sclerosis: a MEG-fMRI study. Neuroscience 403 , pp. 54-69. 10.1016/j.neuroscience.2018.03.018

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Abstract

The process of neurovascular coupling ensures that increases in neuronal activity are fed by increases in cerebral blood flow. Evidence suggests that neurovascular coupling may be impaired in multiple sclerosis (MS) due to a combination of brain hypoperfusion, altered cerebrovascular reactivity and oxygen metabolism, and altered levels of vasoactive compounds. Here, we tested the hypothesis that neurovascular coupling is impaired in MS. We characterised neurovascular coupling as the relationship between changes in neuronal oscillatory power within the gamma frequency band (30-80 Hz), as measured by magnetoencephalography (MEG), and associated haemodynamic changes (blood oxygenation level dependent, BOLD, and cerebral blood flow, CBF) as measured by functional MRI. We characterised these responses in the visual cortex in 13 MS patients and in 10 matched healthy controls by using a reversing checkerboard stimulus at five visual contrasts. There were no significant group differences in visual acuity, P100 latencies, occipital grey matter (GM) volumes and baseline CBF. However, in the MS patients we found a significant reduction in peak gamma power, BOLD and CBF responses. There were no significant differences in neurovascular coupling between groups, in the visual cortex. Our results suggest that neuronal and vascular responses are altered in MS. Gamma power reduction could be an indicator of GM dysfunction, possibly mediated by GABAergic changes. Altered hemodynamic responses confirm previous reports of a vascular dysfunction in MS. Despite altered neuronal and vascular responses, neurovascular coupling appears to be preserved in MS, at least within the range of damage and disability studied here.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine Psychology Cardiff University Brain Research Imaging Centre (CUBRIC)
Publisher:	Elsevier
ISSN:	0306-4522
Date of First Compliant Deposit:	14 March 2018
Date of Acceptance:	13 March 2018
Last Modified:	14 May 2023 21:17
URI:	https://orca.cardiff.ac.uk/id/eprint/109854

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