Synthesis and in vitro anti-HIV activity of N-1,3-benzo[d]thiazol-2-yl-2-(2-oxo-2H-chromen-4-yl)acetamide derivatives using MTT method

Bhavsar, Dhairya, Trivedi, Jalpa, Parekh, Shrey, Savant, Mahesh, Thakrar, Shailesh, Bavishi, Abhay, Radadiya, Ashish ORCID: https://orcid.org/0000-0001-7348-1755, Vala, Hardevsinh, Lunagariya, Jignesh, Parmar, Manisha, Paresh, Ladwa, Loddo, Roberta and Shah, Anamik 2011. Synthesis and in vitro anti-HIV activity of N-1,3-benzo[d]thiazol-2-yl-2-(2-oxo-2H-chromen-4-yl)acetamide derivatives using MTT method. Biorganic and Medicinal Chemistry Letters 21 (11) , pp. 3443-3446. 10.1016/j.bmcl.2011.03.105

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Abstract

A series of novel N-1,3-benzo[d]thiazol-2-yl-2-(2-oxo-2H-chromen-4-yl)acetamide derivatives has been synthesized. All the newly synthesized compounds were evaluated for their anti-HIV activity using MTT method. Most of these compounds showed moderate to potent activity against wild-type HIV-1 with an EC50 ranging from >7 EC50 [μg/ml] to <100 EC50 [μg/ml]. Among them, N-1,3-benzo[d]thiazol-2-yl-2-(2-oxo-2H-chromen-4-yl)acetamide 6v was identified as the most promising compound (EC50 = <7 μg/ml). Among all the compounds, three compounds 6m, 6v and 6u have been exhibits potent anti-HIV activity against MT-4 cells.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Chemistry
Publisher:	Elsevier
ISSN:	0960-894X
Date of Acceptance:	28 March 2011
Last Modified:	23 Oct 2022 13:10
URI:	https://orca.cardiff.ac.uk/id/eprint/109868

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